Sufyan Shahid, Humza Saeed, Minahil Iqbal, Ayesha Batool et al.
BACKGROUND: Intravenous alteplase (ALT) is the standard treatment for acute ischemic stroke (AIS). However, recent trials comparing other tissue plasminogen activators (tPAs) like tenecteplase (TNK) and reteplase with ALT have yielded conflicting results. This necessitated a network meta-analysis to...
Syed Sarmad Javaid, Kainaat ZAHID, Haider Ashfaq, Sara Rahman et al.
BACKGROUND: Heart failure (HF) remains a leading cause of hospitalization globally, exerting significant strain on healthcare systems and impacting patients' quality of life. Seasonal changes in climate and temperature are known to affect HF-related outcomes. This study investigates the seasonal var...
Sufyan Shahid, Mahrosh Kasbati, Samer Adawi, Saniya Ishtiaq et al.
Transcatheter aortic valve replacement (TAVR) is widely used to treat severe aortic stenosis; however, periprocedural stroke remains a significant concern. This systematic review and meta-analysis evaluate whether the use of cerebral embolic protection devices (CEPDs) during TAVR reduces the risk of...
Sufyan Shahid, Minahil Iqbal, Umna Bhatti, Syed Ibrahim Ali et al.
INTRODUCTION Migraine is a leading cause of global disability, yet research on prophylactic interventions remains limited due to unclear underlying mechanisms. We performed a systematic review and meta-analysis to evaluate the comparative efficacy and safety of tricyclic antidepressants (TCAs) versu...
Sufyan Shahid, Ahmedyar Hasan, Minahil Iqbal, Mishal Khan et al.
BACKGROUND Disease-modifying therapies (DMTs) are used to manage multiple sclerosis (MS), particularly in individuals with relapse-onset MS, to slow disease progression, reduce inflammation and demyelination and improve quality of life. Discontinuing treatment may pose a greater relapse risk for you...
Sufyan Shahid, Humza Saeed, Uzair Majeed, Hasnain Wajeeh Saqib et al.
Objective: Mental and behavioral disorders due to psychoactive substance use, as defined by ICD-10 codes F10–F19, include a spectrum of substance use disorders such as acute intoxication, withdrawal, harmful use, and dependence related to alcohol, opioids, stimulants, cannabis, tobacco, and other su...
Hassan Khanzada, Shayan Marsia, Minahil Iqbal, Zuha Tariq et al.
The objective of this study was to conduct a systematic review and meta-analysis to evaluate the performance of smartwatches in detecting obstructive sleep apnea compared with polysomnography.
Shayan Marsia, Minahil Iqbal, Farah Barakat, Sufyan Shahid et al.
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Minahil Iqbal, Muhammad Ahsan Asif, Asma Tahir, Humza Saeed et al.
Background Non-erosive reflux disease (NERD) is characterized by reflux without esophageal erosions. Vonoprazan, a potassium-competitive acid blocker, is recommended for patients with erosive esophagitis (EE). However, its role in NERD, remains limited. We conducted a systematic review and meta-anal...
Sufyan Shahid, Humza Saeed, Minahil Iqbal, Muhammad Aemaz Ur Rehman et al.
We conducted a systematic review and network meta-analysis to assess the efficacy and safety of various tPAs in patients with acute ischemic stroke.