Michael Hoffmann, Craig Hilton‐Taylor, Ariadne Angulo, Monika Böhm et al.
Assessing Biodiversity Declines Understanding human impact on biodiversity depends on sound quantitative projection. Pereira et al. (p. 1496 , published online 26 October) review quantitative scenarios that have been developed for four main areas of concern: species extinctions, species abundances a...
James A Platts-Mills, Jie Liu, Elizabeth T. Rogawski McQuade, Furqan Kabir et al.
BACKGROUND: Optimum management of childhood diarrhoea in low-resource settings has been hampered by insufficient data on aetiology, burden, and associated clinical characteristics. We used quantitative diagnostic methods to reassess and refine estimates of diarrhoea aetiology from the Etiology, Risk...
Elizabeth T. Rogawski McQuade, Jie Liu, James A Platts-Mills, Furqan Kabir et al.
BACKGROUND: Enteropathogen infections in early childhood not only cause diarrhoea but contribute to poor growth. We used molecular diagnostics to assess whether particular enteropathogens were associated with linear growth across seven low-resource settings. METHODS: We used quantitative PCR to dete...
Stephanie R Psaki, Jessica C. Seidman, Mark Miller, Michael Gottlieb et al.
BACKGROUND: There is no standardized approach to comparing socioeconomic status (SES) across multiple sites in epidemiological studies. This is particularly problematic when cross-country comparisons are of interest. We sought to develop a simple measure of SES that would perform well across diverse...
Margaret Kosek, Tahmeed Ahmed, Zulfiqar A Bhutta, Laura E. Caulfield et al.
BACKGROUND: Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populati...
Elizabeth T. Rogawski McQuade, James A Platts-Mills, Jessica C. Seidman, Sushil John et al.
Antibiotics can be a lifesaving treatment for children with bacterial infections and are the most commonly prescribed therapy among all medications given to children. Furthermore, both at the individual and population levels, antibiotic overuse drives the development and transmission of antimicrobia...
Caroline Amour, Jean Gratz, Estomih Mduma, Erling Svensen et al.
BACKGROUND: Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life. METHODS: Children...
Stephanie Psaki, Zulfiqar A Bhutta, Tahmeed Ahmed, Shamsir Ahmed et al.
BACKGROUND: Stunting results from decreased food intake, poor diet quality, and a high burden of early childhood infections, and contributes to significant morbidity and mortality worldwide. Although food insecurity is an important determinant of child nutrition, including stunting, development of u...
Andrew Mertens, Jade Benjamin‐Chung, John M. Colford, Jeremy Coyle et al.
. Interventions such as nutritional supplementation during pregnancy and the postnatal period could help prevent growth faltering, but programmatic action has been insufficient to eliminate the high burden of stunting and wasting in low- and middle-income countries. Identification of age windows and...
Jade Benjamin‐Chung, Andrew Mertens, John M. Colford, Alan Hubbard et al.
. Stunting, a form of linear growth faltering, increases the risk of illness, impaired cognitive development and mortality. Global stunting estimates rely on cross-sectional surveys, which cannot provide direct information about the timing of onset or persistence of growth faltering-a key considerat...
Andrew Mertens, Jade Benjamin‐Chung, John M. Colford, Alan Hubbard et al.
. Prevailing methods to measure wasting rely on cross-sectional surveys that cannot measure onset, recovery and persistence-key features that inform preventive interventions and estimates of disease burden. Here we analyse 21 longitudinal cohorts and show that wasting is a highly dynamic process of ...
Thomas K. Burch, James F. Phillips, John A. Ross
Part 1 The role of family planning programmes as a fertility determinant: introduction, James F.Phillips and John A. Ross the role of family planning programmes as a fertility determinant, Ronald Freedman and Deborah Freedman methods for measuring programme impact - a review of applications in the l...
Benjamin McCormick, Laura E. Murray‐Kolb, Gwenyth O. Lee, Kerry Schulze et al.
BACKGROUND: Environmental enteric dysfunction (EED) is thought to increase the risk of micronutrient deficiencies, but few studies adjust for dietary intakes and systemic inflammation. OBJECTIVE: We tested whether EED is associated with micronutrient deficiency risk independent of diet and systemic ...
Ian Walker, Sushil Baral, Xiaolin Wei, Rumana Huque et al.
The successful treatment of multidrug-resistant tuberculosis (MDR-TB) is a global health priority and a key pillar of the World Health Organization's (WHO's) End TB strategy. There has been significant global investment in diagnostic capabilities in recent years. However, we argue that the mental di...
Sandy Cairncross, Vijay Kochar
PART ONE METHODS AND ISSUES Introduction - Sandy Cairncross Measuring Hygiene Behaviour Health and Hygiene Behaviour - O Massee Bateman Hygiene Behaviour in Epidemiological Perspective Getting Socio-Behavioural Research Done - Vijay Kochar Some Hints for Programme Managers Measuring Hygiene Behaviou...