Md. Mominur Rahman, Md. Saidur Rahaman, Md. Rezaul Islam, Firoza Rahman et al.
Inflammation is a natural protective mechanism that occurs when the body's tissue homeostatic mechanisms are disrupted by biotic, physical, or chemical agents. The immune response generates pro-inflammatory mediators, but excessive output, such as chronic inflammation, contributes to many persistent...
Rekha Khandia, Shailja Singhal, Taha Alqahtani, Mohammad Amjad Kamal et al.
Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and mutating continuously, giving rise to various variants with variable degrees of infectivity and lethality. The virus that initially appeared in China later mutated several times, wreaking havoc and claiming many li...
Chandra Kanta Bhusal, Daniel Ejim Uti, Dattatreya Mukherjee, Taha Alqahtani et al.
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Although the exact etiology of PD remains elusive, growing evidence suggests a complex interplay of genetic, environmental, and...
Musaddique Hussain, Shahzada Khurram Syed, Mobeen Fatima, Saira Shaukat et al.
Acute respiratory distress syndrome (ARDS) is an overwhelming inflammatory disorder of the lung due to direct and indirect insults to the lungs. ARDS is characterized by increased vascular permeability, protein-rich edema, diffuse alveolar infiltrate, and loss of aerated lung tissue, leading to decr...
Trina Ekawati Tallei, Fatimawali Fatimawali, Afriza Yelnetty, Rinaldi Idroes et al.
The rapid spread of a novel coronavirus known as SARS-CoV-2 has compelled the entire world to seek ways to weaken this virus, prevent its spread and also eliminate it. However, no drug has been approved to treat COVID-19. Furthermore, the receptor-binding domain (RBD) on this viral spike protein, as...
Utsang Kumar, Rekha Khandia, Shailja Singhal, Nidhi Puranik et al.
Uneven codon usage within genes as well as among genomes is a usual phenomenon across organisms. It plays a significant role in the translational efficiency and evolution of a particular gene. EPB41L3 is a tumor suppressor protein-coding gene, and in the present study, the pattern of codon usage was...
Ejaz Rasool Dar, Mudasir Bashir Gugjoo, Moien Javaid, Shahid Hussain et al.
The current study demonstrates the culture characteristics of adipose tissue and bone marrow-derived mesenchymal stem cells (MSC). The study evaluates the effect of ambient temperature, physiological status of the donor and the tissue source on sheep (Ovis aries) mesenchymal stem cells. The tissue s...
Arghya Bhattacharya, Manas Chakraborty, Ananya Chanda, Taha Alqahtani et al.
Recent advancements in neuroendocrinology challenge the long-held belief that hormonal effects are confined to perivascular tissues and do not extend to the central nervous system (CNS). This paradigm shift, propelled by groundbreaking research, reveals that synthetic hormones, notably in anti-infla...
Popat Mohite, Abhijeet Puri, Roshan Dave, Aarati Budar et al.
This review explores the application of induced pluripotent stem cells (iPSCs) in regenerative medicine. The therapeutic significance of iPSC-derived cell therapy within regenerative medicine, emphasizes their reprogramming process and crucial role in cellular differentiation while setting the purpo...
Taha Alqahtani, Rekha Khandia, Nidhi Puranik, Ali Alqahtani et al.
Dementia is a clinical syndrome characterized by progressive cognitive decline, and the symptoms could be gradual, persistent, and progressive. In the present study, we investigated 47 genes that have been linked to dementia. Compositional, selectional, and mutational forces were seen to be involved...
Rekha Khandia, Anushri Sharma, Taha Alqahtani, Ali Alqahtani et al.
Neurodegenerative disorders cause irreversible damage to the neurons and adversely affect the quality of life. Protein misfolding and their aggregation in specific parts of the brain, mitochondrial dysfunction, calcium load, proteolytic stress, and oxidative stress are among the causes of neurodegen...
Jaerdyson M. da Rocha, Daniel Melo de Oliveira Campos, Stephany Campanelli, Gabriela de Lima Menezes et al.
Ebola virus disease (EVD) causes outbreaks and epidemics in West Africa that persist until today. The envelope glycoprotein of Ebola virus (GP) consists of two subunits, GP1 and GP2, and plays a key role in anchoring or fusing the virus to the host cell in its active form on the virion surface. Tore...
Jehad Zuhair Tayyeb, Shibam Mondal, Md. Anisur Rahman, Swapon Kumar et al.
Gastric cancer is considered a class 1 carcinogen that is closely linked to infection with Helicobacter pylori (H. pylori), which affects over 1 million people each year. However, the major challenge to fight against H. pylori and its associated gastric cancer due to drug resistance. This research g...
Mohammad Fazle Rabbi, Kamarul Hawari Ghazali, Omar Altwijri, Mahdi Alqahtani et al.
Diabetic neuropathy is one of the physical complications of diabetes mellitus (DM) patients with a long history of diabetes. An electromyography (EMG)-based assessment may be very useful for the management of diabetic neuropathy. In the present study, we aimed to summarize all of the findings and re...
Saurav Kumar Mishra, Moahmed Shaheen, Sharifa Sultana, Al-Anood M. Al-Dies et al.
Cervical cancer remains a major global health challenge, largely driven by persistent infections with high-risk human papillomavirus (HPV). Although preventive vaccines have reduced cervical cancer incidence in some settings, effective therapeutic strategies for established HPV-associated malignanci...