Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska et al.
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. ...
Martin J. Garland, Katarzyna Migalska, Tuan Mazlelaa Tuan Mahmood, Thakur Raghu Raj Singh et al.
In order to exploit the transdermal route for systemic delivery of a wide range of drug molecules, including peptide/protein molecules and genetic material, a means of disrupting the excellent barrier properties of the uppermost layer of the skin, the stratum corneum, must be sought. The use of micr...
Ravi Sheshala, Gan Chew Hong, Wong Pui Yee, Venkata Srikanth Meka et al.
The objectives of this study were to develop biodegradable poly-lactic-co-glycolic acid (PLGA) based injectable phase inversion in situ forming system for sustained delivery of triamcinolone acetonide (TA) and to conduct physicochemical characterisation including in vitro drug release of the prepare...
Thakur Raghu Raj Singh, A. David Woolfson, Ryan F. Donnelly
Abstract Objectives Swelling kinetics and solute permeation (theophylline, vitamin B12 and fluorescein sodium) of hydrogels composed of poly(methyl vinyl ether-co-maleic acid) (PMVE/MA) and poly(ethylene glycol) (PEG) are presented. Methods The effects of PMVE/MA and PEG 10 000 content on swelling b...
Thakur Raghu Raj Singh, David S. Jones
Ophthalmic delivery of drug molecules has been a major challenge to both pharmacologists and drug delivery scientists. This is due to the unique anatomy and physiology of the eye. These challenges are primarily posed by various barriers of the eye, which are dependent upon the route of administratio...
Alyaa A. Albadr, Ismaiel A. Tekko, Lalitkumar K. Vora, Ahlam Ali et al.
Chronic fungal infection of the cornea could lead to blindness if not treated properly. Topical AMP-B is considered the first treatment of choice for ocular fungal infection. However, factors related to its poor solubility and penetration through intact cornea leads to poor bioavailability. Micronee...
John Echeverri‐Gent
Click to increase image sizeClick to decrease image size Notes The author wishes to express special appreciation to Ajay Shah and Susan Thomas for their gracious help and in some cases co-participation in fieldwork, as well as for their generous sharing of their ideas about India's equity markets. A...
Raghu Raj Singh Thakur, Samer Adwan, Ismaiel A. Tekko, Karim Soliman et al.
Scleral and corneal membranes represent substantial barriers against drug delivery to the eye. Conventional hypodermic needles-based intraocular injections are clinically employed to overcome these barriers. This study, for the first time, investigated a non-invasive alternative to intraocular injec...
Deepakkumar Mishra, Hákon Hrafn Sigurðsson, Ana Paula Serro, Giedrius Kalesnykas et al.
Choroidal neovascularization (CNV) is one of the hallmark symptoms of Wet Age-related Macular Degeneration (wAMD) and DiabeticRetinopathy(DR) which involves formation of neoangiogenic i.e. formation of new abnormal blood vessels emerging from the choroidal blood vessels and protruding through the re...
Shilpkala Gade, Eneko Larrañeta, Ryan F. Donnelly, Rocío Herrero‐Vanrell et al.
Age-related macular degeneration (AMD) is a potentially blinding posterior segment disease; inflammatory responses and subretinal drusen formation lead to leaky blood vessels. The current treatment method involves intravitreal injections of anti-VEGF agents, which is highly invasive and requires fre...
Shubhamkumar M. Baviskar, Lalit Vora, AnnMarie Hipsley, Edwin Price et al.
Abdul‐Salam Jahanfo Abdulai, Sangita Agarwal, Nufile Uddin Ahmed, Waqas Ali et al.