Salim Yusuf, Sumathy Rangarajan, Koon Teo, Shofiqul Islam et al.
BACKGROUND: More than 80% of deaths from cardiovascular disease are estimated to occur in low-income and middle-income countries, but the reasons are unknown. METHODS: We enrolled 156,424 persons from 628 urban and rural communities in 17 countries (3 high-income, 10 middle-income, and 4 low-income ...
Andrew Mente, Martin O’Donnell, Sumathy Rangarajan, Matthew McQueen et al.
BACKGROUND: Higher levels of sodium intake are reported to be associated with higher blood pressure. Whether this relationship varies according to levels of sodium or potassium intake and in different populations is unknown. METHODS: We studied 102,216 adults from 18 countries. Estimates of 24-hour ...
Rasha Khatib, Martin McKee, Harry S. Shannon, Clara K Chow et al.
BACKGROUND WHO has targeted that medicines to prevent recurrent cardiovascular disease be available in 80% of communities and used by 50% of eligible individuals by 2025. We have previously reported that use of these medicines is very low, but now aim to assess how such low use relates to their lack...
Neeraj Narula, Emily C L Wong, Mahshid Dehghan, Andrew Mente et al.
OBJECTIVE: To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD). DESIGN: Prospective cohort study. SETTING: 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle Eas...
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Matthew McQueen et al.
Background The relation between dietary nutrients and cardiovascular disease risk markers in many regions worldwide is unknown. In this study, we investigated the effect of dietary nutrients on blood lipids and blood pressure, two of the most important risk factors for cardiovascular disease, in low...
Thomas A. Gaziano, Shafika Abrahams‐Gessel, Catalina A. Denman, Carlos Mendoza Montano et al.
BackgroundCardiovascular disease contributes substantially to the non-communicable disease (NCD) burden in low-income and middle-income countries, which also often have substantial health personnel shortages. In this observational study we investigated whether community health workers could do commu...
Perry Hystad, MyLinh Duong, Michael Bräuer, Andrew Larkin et al.
BACKGROUND: Household air pollution (HAP) from solid fuel use for cooking affects 2.5 billion individuals globally and may contribute substantially to disease burden. However, few prospective studies have assessed the impact of HAP on mortality and cardiorespiratory disease. OBJECTIVES: Our goal was...
Sumathi Swaminathan, Mahshid Dehghan, John Michael Raj, Tinku Thomas et al.
OBJECTIVE: To evaluate the association between intakes of refined grains, whole grains, and white rice with cardiovascular disease, total mortality, blood lipids, and blood pressure in the Prospective Urban and Rural Epidemiology (PURE) study. DESIGN: Prospective cohort study. SETTING: PURE study in...
Ryo Naito, Darryl P. Leong, Shrikant I. Bangdiwala, Martin McKee et al.
OBJECTIVE: To examine the association between social isolation and mortality and incident diseases in middle-aged adults in urban and rural communities from high-income, middle-income and low-income countries. DESIGN: Population-based prospective observational study. SETTING: Urban and rural communi...
Adrianna Murphy, Benjamin Palafox, Owen O’Donnell, David Stückler et al.
BACKGROUND: There is little evidence on the use of secondary prevention medicines for cardiovascular disease by socioeconomic groups in countries at different levels of economic development. METHODS: We assessed use of antiplatelet, cholesterol, and blood-pressure-lowering drugs in 8492 individuals ...
Raphael E. Arku, Michael Bräuer, Suad Hashim Ahmed, Khalid F. AlHabib et al.
Exposure to air pollution has been linked to elevated blood pressure (BP) and hypertension, but most research has focused on short-term (hours, days, or months) exposures at relatively low concentrations. We examined the associations between long-term (3-year average) concentrations of outdoor PM2.5...
Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Viswanathan Mohan et al.
BACKGROUND Higher intake of ultra-processed foods (UPFs) has been associated with increased risk of CVD and mortality in observational studies from Western countries but data from non-Western countries are limited. OBJECTIVES We aimed to assess the association between consumption of UPFs and risk of...
Shafika Abrahams‐Gessel, Catalina A. Denman, Carlos Mendoza Montano, Thomas A. Gaziano et al.
BACKGROUND: Cardiovascular disease (CVD) is on the rise in low- and middle-income countries and is proving difficult to combat due to the emphasis on improving outcomes in maternal and child health and infectious diseases against a backdrop of severe human resource and infrastructure constraints. Ef...
Naomi Levitt, Thandi Puoane, Catalina A. Denman, Shafika Abrahams‐Gessel et al.
BACKGROUND: We have found that community health workers (CHWs) with appropriate training are able to accurately identify people at high cardiovascular disease (CVD) risk in the community who would benefit from the introduction of preventative management, in Bangladesh, Guatemala, Mexico, and South A...
Shafika Abrahams‐Gessel, Catalina A. Denman, Carlos Mendoza Montano, Thomas A. Gaziano et al.
BACKGROUND: Community health workers (CHW) can screen for cardiovascular disease risk as well as health professionals using a noninvasive screening tool. However, this demonstrated success does not guarantee effective scaling of the intervention to a population level. OBJECTIVES: This study sought t...
Matthew Shupler, Perry Hystad, Paul Gustafson, Sumathy Rangarajan et al.
INTRODUCTION: Switching from polluting (e.g. wood, crop waste, coal) to clean cooking fuels (e.g. gas, electricity) can reduce household air pollution (HAP) exposures and climate-forcing emissions. While studies have evaluated specific interventions and assessed fuel-switching in repeated cross-sect...
Philip Joseph, Álvaro Avezum, Chinthanie Ramasundarahettige, Prem Mony et al.
BACKGROUND: It is unclear whether global use of medications for secondary cardiovascular (CVD) prevention is improving over time. OBJECTIVES: This study across 17 high-, middle- and low-income countries described variations in secondary CVD prevention medication use over a median follow-up of 12 yea...
Ying Wang, MyLinh Duong, Michael Bräuer, Sumathy Rangarajan et al.
Background: Globally, household air pollution (HAP) is a major environmental hazard that affects respiratory health. However, few studies have examined associations between HAP and lung function decline and respiratory disease and mortality. Methods: We used data from the Prospective Urban and Rural...
MyLinh Duong, Sumathy Rangarajan, Michele Zaman, Nafiza Mat Nasir et al.
INTRODUCTION: Portable spirometers are commonly used in longitudinal epidemiological studies to measure and track the forced expiratory volume in first second (FEV1) and forced vital capacity (FVC). During the course of the study, it may be necessary to replace spirometers with a different model. Th...