Florian Marks, Vera von Kalckreuth, Peter Aaby, Yaw Adu‐Sarkodie et al.
BACKGROUND: Available incidence data for invasive salmonella disease in sub-Saharan Africa are scarce. Standardised, multicountry data are required to better understand the nature and burden of disease in Africa. We aimed to measure the adjusted incidence estimates of typhoid fever and invasive non-...
Sujit Bhattacharya, Dipika Sur, Mohammad Ali, Suman Kanungo et al.
Background Efficacy and safety of a two-dose regimen of bivalent killed whole-cell oral cholera vaccine (Shantha Biotechnics, Hyderabad, India) to 3 years is established, but long-term efficacy is not. We aimed to assess protective efficacy up to 5 years in a slum area of Kolkata, India. Methods In ...
Firdausi Qadri, Thomas F. Wierzba, Mohammad Ali, Fahima Chowdhury et al.
BACKGROUND: A single-dose regimen of the current killed oral cholera vaccines that have been prequalified by the World Health Organization would make them more attractive for use against endemic and epidemic cholera. We conducted an efficacy trial of a single dose of the killed oral cholera vaccine ...
A. Louis Bourgeois, Thomas F. Wierzba, Richard I. Walker
Enterotoxigenic Escherichia coli (ETEC) is one of the most common bacterial causes of diarrhea-associated morbidity and mortality, particularly among infants and young children in developing countries. Still, the true impact on child and traveler health is likely underestimated. There are currently ...
Ibrahim Khalil, Richard I. Walker, Chad K. Porter, Farzana Muhib et al.
Diarrhoeal disease attributable to enterotoxigenic Escherichia coli (ETEC) causes substantial morbidity and mortality predominantly in paediatric populations in low- and middle-income countries. In addition to acute illness, there is an increasing appreciation of the long-term consequences of enteri...
Firdausi Qadri, Marjahan Akhtar, Taufiqur Rahman Bhuiyan, Mohiul Islam Chowdhury et al.
BACKGROUND: Enterotoxigenic Escherichia coli causes diarrhoea, leading to substantial mortality and morbidity in children, but no specific vaccine exists. This trial tested an oral, inactivated, enterotoxigenic E coli vaccine (ETVAX), which has been previously shown to be safe and highly immuongenic...
Vera von Kalckreuth, Frank Konings, Peter Aaby, Yaw Adu‐Sarkodie et al.
BACKGROUND: New immunization programs are dependent on data from surveillance networks and disease burden estimates to prioritize target areas and risk groups. Data regarding invasive Salmonella disease in sub-Saharan Africa are currently limited, thus hindering the implementation of preventive meas...
Firdausi Qadri, Mohammad Ali, Julia Lynch, Fahima Chowdhury et al.
BACKGROUND: A single-dose regimen of inactivated whole-cell oral cholera vaccine (OCV) is attractive because it reduces logistical challenges for vaccination and could enable more people to be vaccinated. Previously, we reported the efficacy of a single dose of an OCV vaccine during the 6 months fol...
Carine Ronsmans, MichaelL. Bennish, Thomas F. Wierzba
To develop guidelines for community health workers in the treatment of patients with diarrhoea, diarrhoea prevalence was actively surveyed for a year in a remote rural community of 915,000 persons, and the enteric pathogens and clinical features associated with diarrhoeal illness were determined in ...
Se Eun Park, Gi Deok Pak, Peter Aaby, Yaw Adu‐Sarkodie et al.
BACKGROUND: Country-specific studies in Africa have indicated that Plasmodium falciparum is associated with invasive nontyphoidal Salmonella (iNTS) disease. We conducted a multicenter study in 13 sites in Burkina Faso, Ethiopia, Ghana, Guinea-Bissau, Kenya, Madagascar, Senegal, South Africa, Sudan, ...
Marjahan Akhtar, Mohiul Islam Chowdhury, Taufiqur Rahman Bhuiyan, Joanna Kaim et al.
The safety and immunogenicity of the second generation oral enterotoxigenic Escherichia coli (ETEC) vaccine ETVAX, consisting of inactivated recombinant E. coli strains over-expressing the colonization factors (CFs) CFA/I, CS3, CS5 and CS6 and the heat labile toxoid LCTBA, were evaluated in Banglade...
Michael L. Bennish, A Eusof, Bradford A. Kay, Thomas F. Wierzba
Hassan M. Al‐Emran, Daniel Eibach, Ralf Krumkamp, Mohammad Ali et al.
BACKGROUND: Salmonella enterica serovar Typhi is a predominant cause of bloodstream infections in sub-Saharan Africa (SSA). Increasing numbers of S. Typhi with resistance to ciprofloxacin have been reported from different parts of the world. However, data from SSA are limited. In this study, we aime...
Rubhana Raqib, Protim Sarker, Khalequ Zaman, Nur Alam et al.
Shigella sonnei live vaccine candidate, WRSS1, which was previously evaluated in US, Israeli and Thai volunteers, was administered orally to Bangladeshi adults and children to assess its safety, clinical tolerability and immunogenicity. In a randomized, placebo-controlled, dose-escalation, age-desce...
Suman Kanungo, Sachin N. Desai, Ranjan K. Nandy, Mihir Kumar Bhattacharya et al.
BACKGROUND: A bivalent killed whole cell oral cholera vaccine has been found to be safe and efficacious for five years in the cholera endemic setting of Kolkata, India, when given in a two dose schedule, two weeks apart. A randomized controlled trial revealed that the immune response was not signifi...