Christopher Troeger, Ibrahim A. Khalil, Puja C Rao, Shujin Cao et al.
Importance: Rotavirus infection is the global leading cause of diarrhea-associated morbidity and mortality among children younger than 5 years. Objectives: To examine the extent of rotavirus infection among children younger than 5 years by country and the number of deaths averted because of the rota...
Vincent Hsu, M. Jahangir Hossain, Umesh D. Parashar, Mohammed Monsur Ali et al.
We retrospectively investigated two outbreaks of encephalitis in Meherpur and Naogaon, Bangladesh, which occurred in 2001 and We collected serum samples from persons who were ill, their household contacts, randomly selected residents, hospital workers, and various animals. Cases were classified as l...
Devy Emperador, Daniel E. Velásquez, Concepción F. Estívariz, Ben Lopman et al.
BACKGROUND: Trivalent oral poliovirus vaccine (OPV) is known to interfere with monovalent rotavirus vaccine (RV1) immunogenicity. The interference caused by bivalent and monovalent OPV formulations, which will be increasingly used globally in coming years, has not been examined. We conducted a post ...
Melody G. Miles, Kristen Lewis, Gagandeep Kang, Umesh D. Parashar et al.
Of the estimated half-million deaths from rotavirus globally each year, approximately one-third (N = 160,000 deaths) occur in the Indian subcontinent (defined as India, Bangladesh, and Pakistan). Two commercial vaccines are available for use and recommended by WHO, although the prohibitive vaccine p...
Samarasimha Reddy N, Nayana P. Nair, Jacqueline E. Tate, Varunkumar Thiyagarajan et al.
BACKGROUND: A three-dose, oral rotavirus vaccine (Rotavac) was introduced in the universal immunization program in India in 2016. A prelicensure trial involving 6799 infants was not large enough to detect a small increased risk of intussusception. Postmarketing surveillance data would be useful in a...
Syed M Satter, Paul A. Gastañaduy, Khaleda Islam, Mahmudur Rahman et al.
BACKGROUND: In anticipation of introduction of a rotavirus vaccine into the national immunization program of Bangladesh, active hospital-based surveillance was initiated to provide prevaccine baseline data on rotavirus disease. METHODS: Children 5 years of age and younger admitted with acute gastroe...
Clint Pecenka, Umesh D. Parashar, Jacqueline E. Tate, Jahangir Khan et al.
INTRODUCTION: Diarrheal disease is a leading cause of child mortality globally, and rotavirus is responsible for more than a third of those deaths. Despite substantial decreases, the number of rotavirus deaths in children under five was 215,000 per year in 2013. Of these deaths, approximately 41% oc...
Khalequ Zaman, Jessica A. Fleming, John C. Victor, Mohammad Yunus et al.
BACKGROUND: The burden of rotavirus morbidity and mortality is high in children aged <5 years in developing countries, and evaluations indicate waning protection from rotavirus immunization in the second year. An additional dose of rotavirus vaccine may enhance the immune response and lengthen the p...
Go Tanaka, Shah M. Faruque, Stephen P. Luby, M. A. Malek et al.
BACKGROUND: To assess the potential health benefits of introducing new rotavirus (RV) vaccines, we estimated mortality from RV gastroenteritis in Bangladeshi children <5 years of age. METHODS: We examined data from ongoing diarrhea surveillance in a systematic 2% sample (4% until 1995) of patients v...
Eleanor Burnett, Furqan Kabir, Nguyễn Vân Trang, Ajit Rayamajhi et al.
BACKGROUND: The etiology of intussusception, the leading cause of bowel obstruction in infants, is unknown in most cases. Adenovirus has been associated with intussusception and slightly increased risk of intussusception with rotavirus vaccination has been found. We conducted a case-control study am...
Syed M Satter, Negar Aliabadi, Paul A. Gastañaduy, Warda Haque et al.
Introduction: In preparation for the introduction of a rotavirus vaccine into the routine immunization program of Bangladesh in 2018, we report data and highlight evolving genotypes from five years of active hospital-based rotavirus surveillance which began in July 2012. Methods: We enrolled and col...
Syed M Satter, Negar Aliabadi, Catherine Yen, Paul A. Gastañaduy et al.
INTRODUCTION: Rotavirus vaccines have significantly decreased the burden of diarrheal diseases in countries that have introduced them into their immunization programs. In some studies, there has been a small association between rotavirus vaccines and intussusception in post-marketing surveillance, h...
Sayem Ahmed, Farzana Dorin, Syed M Satter, Abdur Razzaque Sarker et al.
Background: Rotavirus is a common cause of severe acute gastroenteritis among young children. Estimation of the economic burden would provide informed decision about vaccine investment, which has been a potential policy discussion in Bangladesh for several years. Methods: We estimated the societal c...
Syed Moinuddin Satter, Zarin Abdullah, Farzana Fariha, Yeasir Karim et al.
BACKGROUND: Norovirus is a major cause of endemic acute gastroenteritis (AGE) worldwide. We described the epidemiology, risk factors, and genotypic distribution of noroviruses among hospitalized patients of all ages in Bangladesh. METHODS: From March 2018 to October 2021, 1250 AGE case patients and ...
Daniel E Velasquez-Portocarrero, Xiaoqian Wang, Margaret M. Cortese, Cynthia J. Snider et al.
Background A head-to-head comparison of the most widely used oral rotavirus vaccines has not previously been done, particularly in a high child mortality setting. We therefore aimed to compare the immunogenicity of RotaTeq (Merck, Kenilworth, NJ, USA) and Rotarix (GlaxoSmithKline, Rixensart, Belgium...