Xinyu Chen, Majd Ariss, Gopalakrishnan Ramakrishnan, Véronique Nogueira et al.
Studies in three mouse models of breast cancer identified profound discrepancies between cell-autonomous and systemic Akt1- or Akt2-inducible deletion on breast cancer tumorigenesis and metastasis. Although systemic Akt1 deletion inhibits metastasis, cell-autonomous Akt1 deletion does not. Single-ce...
Xinyu Chen, Majd Ariss, Gopalkrishnan Ramakrishnan, Véronique Nogueira et al.
Abstract Studies in three mouse models of breast cancer identified profound discrepancies between cell autonomous and systemic Akt1 or Akt2 deletion on breast cancer tumorigenesis and metastasis. First, unlike systemic Akt1 deletion, which inhibits metastasis, cell autonomous Akt1 deletion does not....