Varsha Jain, Luis Rivera, Khalequ Zaman, Roberto A. Espos et al.
BACKGROUND: Commonly used trivalent vaccines contain one influenza B virus lineage and may be ineffective against viruses of the other B lineage. We evaluated the efficacy of a candidate inactivated quadrivalent influenza vaccine (QIV) containing both B lineages. METHODS: In this multinational, phas...
Carine Claeys, Khalequ Zaman, Ghassan Dbaibo, Ping Li et al.
Background Despite the importance of vaccinating children younger than 5 years, few studies evaluating vaccine prevention of influenza have been reported in this age group. We evaluated efficacy of an inactivated quadrivalent influenza vaccine (IIV4) in children aged 6-35 months. Methods In this pha...
Ghassan Dbaibo, Arshad Amanullah, Carine Claeys, Allen Izu et al.
BACKGROUND: We evaluated an inactivated quadrivalent influenza vaccine (IIV4) in children 6-35 months of age in a phase III, observer-blind trial. METHODS: The aim of this analysis was to estimate vaccine efficacy (VE) in preventing laboratory-confirmed influenza in each of 5 independent seasonal co...
Jasur Danier, Luis Rivera, Carine Claeys, Ghassan Dbaibo et al.
BACKGROUND: In an exploratory analysis of an inactivated quadrivalent influenza vaccine (IIV4) trial in children 6-35 months without risk factors for influenza, we evaluated clinical presentation of influenza illness and vaccine impact on health outcomes. METHODS: This phase III trial was conducted ...
Thomas D. Stanton, Shaun P Keegan, Jabir A Abdulahi, Anne V Amulele et al.
Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could avert ~400,000 cases and ~80,000 deaths annually, mostly in Africa and South Asia. Vaccine formulations ...
Carine Claeys, Mamadou Dramé, José García-Sicilia, Khalequ Zaman et al.
BACKGROUND: GSK has modified the licensed monovalent bulk manufacturing process for its split-virion inactivated quadrivalent influenza vaccine (IIV4) to harmonize the process among different strains, resulting in an increased number of finished vaccine doses, while compensating for the change from ...
Thomas D. Stanton, Shaun P Keegan, Jabir A. Abdulahi, Anne V. Amulele et al.
BACKGROUND: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against ≥70% of K. pneumoniae infections, could avert ~400,000 cases and ~80,000 deaths annually, mostly in Africa and South Asia. Vaccine formulations...
Varsha Choudhary, Prabhat Kiran Khatri, Palak Khinvasara, G.K. Aseri et al.
Arun Kumar Dubey, Achin Jain, Sarjana Singh, Sudhakar Kumar et al.
The Internet has seen significant improvements in the number and type of web over the past few years. Resources such as online banking, gambling, and social networking sites have improved. As a result, large amounts of data are uploaded to the Internet daily. However, the Internet can be used as a t...