Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Habibul Ahsan et al.
Exposure to manganese via inhalation has long been known to elicit neurotoxicity in adults, but little is known about possible consequences of exposure via drinking water. In this study, we report results of a cross-sectional investigation of intellectual function in 142 10-year-old children in Arai...
Maria Argos, Tara Kalra, Paul J. Rathouz, Yu Chen et al.
Background Millions of people worldwide are chronically exposed to arsenic through drinking water, including 35–77 million people in Bangladesh. The association between arsenic exposure and mortality rate has not been prospectively investigated by use of individual-level data. We therefore prospecti...
Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Habibul Ahsan et al.
Exposure to arsenic has long been known to have neurologic consequences in adults, but to date there are no well-controlled studies in children. We report results of a cross-sectional investigation of intellectual function in 201 children 10 years of age whose parents participate in our ongoing pros...
Yu Chen, J. H. Graziano, F. Parvez, Mengling Liu et al.
OBJECTIVE: To evaluate the association between arsenic exposure and mortality from cardiovascular disease and to assess whether cigarette smoking influences the association. DESIGN: Prospective cohort study with arsenic exposure measured in drinking water from wells and urine. SETTING: General popul...
Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Habibul Ahsan et al.
BACKGROUND: We recently reported results of a cross-sectional investigation of intellectual function in 10-year-olds in Bangladesh, who had been exposed to arsenic from drinking water in their home wells. OBJECTIVES: We present results of a similar investigation of 301 randomly selected 6-year-olds ...
Habibul Ahsan, Yu Chen, Faruque Parvez, Lydia B. Zablotska et al.
Millions of persons around the world are exposed to low doses of arsenic through drinking water. However, estimates of health effects associated with low-dose arsenic exposure have been extrapolated from high-dose studies. In Bangladesh, many persons have been exposed to a wide range of doses of ars...
Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Pam Factor‐Litvak et al.
Recently, epidemiologic studies of developmental neurotoxicology have been challenged to increase focus on co-exposure to multiple toxicants. Earlier reports, including our own work in Bangladesh, have demonstrated independent associations between neurobehavioral function and exposure to both arseni...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Chronic exposure to arsenic is occurring throughout South and East Asia due to groundwater contamination of well water. Variability in susceptibility to arsenic toxicity may be related to nutritional status. Arsenic is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via one...
Khalid Khan, Gail A. Wasserman, Xinhua Liu, Ershad Ahmed et al.
Drinking water manganese (WMn) is a potential threat to children’s health due to its associations with a wide range of outcomes including cognitive, behavioral and neuropsychological effects. Although adverse effects of Mn on cognitive function of the children indicate possible impact on their acade...
Mary V. Gamble, Xinhua Liu, Habibul Ahsan, J. Richard Pilsner et al.
Background Populations in South and East Asia and many other regions of the world are chronically exposed to arsenic-contaminated drinking water. To various degrees, ingested inorganic arsenic (InAs) is methylated to monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) via folate-dependent on...
Alexander van Geen, Habibul Ahsan, A. Horneman, Ratan Dhar et al.
OBJECTIVE: To survey tube wells and households in Araihazar upazila, Bangladesh, to set the stage for a long-term epidemiological study of the consequences of chronic arsenic exposure. METHODS: Water samples and household data were collected over a period of 4 months in 2000 from 4997 contiguous tub...
Faruque Parvez, Gail A. Wasserman, Pam Factor‐Litvak, Xinhua Liu et al.
BACKGROUND: Several reports indicate that drinking water arsenic (WAs) and manganese (WMn) are associated with children's intellectual function. Very little is known, however, about possible associations with other neurologic outcomes such as motor function. METHODS: We investigated the associations...
Khalid Khan, Pam Factor‐Litvak, Gail A. Wasserman, Xinhua Liu et al.
Background: Evidence of neurological, cognitive, and neuropsychological effects of manganese (Mn) exposure from drinking water (WMn) in children has generated widespread public health concern. At elevated exposures, Mn has been associated with increased levels of externalizing behaviors, including i...
Habibul Ahsan, Yu Chen, Muhammad G. Kibriya, Vesna Slavkovich et al.
We conducted a case-control study to investigate interindividual variability in susceptibility to health effects of inorganic arsenic due to arsenic metabolism efficiency, genetic factors, and their interaction. A total of 594 cases of arsenic-induced skin lesions and 1,041 controls was selected fro...
J. Richard Pilsner, Xinhua Liu, Habibul Ahsan, Vesna Ilievski et al.
Background Studies in cell culture and animal models indicate that arsenic exposure induces modifications in DNA methylation, including genome-wide DNA hypomethylation. It is not known whether arsenic exposure influences genomic DNA methylation in human populations chronically exposed to arsenic-con...