Salim Yusuf, Philip Joseph, Sumathy Rangarajan, Shofiqul Islam et al.
Background: Global estimates of the impact of common modifiable risk factors on cardiovascular disease (CVD) and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban Rural Epidemiology (PURE) study overcomes these limitations by using simila...
Darryl P. Leong, Koon Teo, Sumathy Rangarajan, Patricio López‐Jaramillo et al.
BACKGROUND Reduced muscular strength, as measured by grip strength, has been associated with an increased risk of all-cause and cardiovascular mortality. Grip strength is appealing as a simple, quick, and inexpensive means of stratifying an individual's risk of cardiovascular death. However, the pro...
Mahshid Dehghan, Andrew Mente, Xiaohe Zhang, Sumathi Swaminathan et al.
Background The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition excess is more likely, so their applicability to other populations is unclear. Methods The Prospective Ur...
Salim Yusuf, Sumathy Rangarajan, Koon Teo, Shofiqul Islam et al.
BACKGROUND: More than 80% of deaths from cardiovascular disease are estimated to occur in low-income and middle-income countries, but the reasons are unknown. METHODS: We enrolled 156,424 persons from 628 urban and rural communities in 17 countries (3 high-income, 10 middle-income, and 4 low-income ...
Victoria Miller, Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan et al.
BACKGROUND The association between intake of fruits, vegetables, and legumes with cardiovascular disease and deaths has been investigated extensively in Europe, the USA, Japan, and China, but little or no data are available from the Middle East, South America, Africa, or south Asia. METHODS We did a...
Gilles R. Dagenais, Darryl P. Leong, Sumathy Rangarajan, Fernando Laņas et al.
BACKGROUND To our knowledge, no previous study has prospectively documented the incidence of common diseases and related mortality in high-income countries (HICs), middle-income countries (MICs), and low-income countries (LICs) with standardised approaches. Such information is key to developing glob...
Annika Rosengren, Andrew Smyth, Sumathy Rangarajan, Chinthanie Ramasundarahettige et al.
BACKGROUND: Socioeconomic status is associated with differences in risk factors for cardiovascular disease incidence and outcomes, including mortality. However, it is unclear whether the associations between cardiovascular disease and common measures of socioeconomic status-wealth and education-diff...
Victoria Miller, Salim Yusuf, Clara K Chow, Mahshid Dehghan et al.
BACKGROUND: Several international guidelines recommend the consumption of two servings of fruits and three servings of vegetables per day, but their intake is thought to be low worldwide. We aimed to determine the extent to which such low intake is related to availability and affordability. METHODS:...
Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Patrick Sheridan et al.
BACKGROUND Dietary guidelines recommend minimising consumption of whole-fat dairy products, as they are a source of saturated fats and presumed to adversely affect blood lipids and increase cardiovascular disease and mortality. Evidence for this contention is sparse and few data for the effects of d...
Chuangshi Wang, Shrikant I. Bangdiwala, Sumathy Rangarajan, Scott A. Lear et al.
AIMS: To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events. METHODS AND RESULTS: We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time a...
Rasha Khatib, Martin McKee, Harry S. Shannon, Clara K Chow et al.
BACKGROUND WHO has targeted that medicines to prevent recurrent cardiovascular disease be available in 80% of communities and used by 50% of eligible individuals by 2025. We have previously reported that use of these medicines is very low, but now aim to assess how such low use relates to their lack...
Patricio López‐Jaramillo, Diego Gómez-Arbeláez, Daniel Martínez-Bello, Marc Evans M. Abat et al.
BackgroundThe triglyceride glucose (TyG) index is an easily accessible surrogate marker of insulin resistance, an important pathway in the development of type 2 diabetes and cardiovascular diseases. However, the association of the TyG index with cardiovascular diseases and mortality has mainly been ...
Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Matthew McQueen et al.
Background The relation between dietary nutrients and cardiovascular disease risk markers in many regions worldwide is unknown. In this study, we investigated the effect of dietary nutrients on blood lipids and blood pressure, two of the most important risk factors for cardiovascular disease, in low...
Adrianna Murphy, Benjamin Palafox, Marjan Walli-Attaei, Timothy Powell‐Jackson et al.
Background: Non-communicable diseases (NCDs) are the leading cause of death globally. In 2014, the United Nations committed to reducing premature mortality from NCDs, including by reducing the burden of healthcare costs. Since 2014, the Prospective Urban and Rural Epidemiology (PURE) Study has been ...
David J.A. Jenkins, Mahshid Dehghan, Andrew Mente, Shrikant I. Bangdiwala et al.
BACKGROUND: Most data regarding the association between the glycemic index and cardiovascular disease come from high-income Western populations, with little information from non-Western countries with low or middle incomes. To fill this gap, data are needed from a large, geographically diverse popul...