Reingard Raml, Alice Rumpler, Walter Goessler, Marie Vahter et al.
Over the last 6 years, much work on arsenic species in urine samples has been directed toward the determination of the reduced dimethylated arsenic species, DMA(III), because of its high toxicity and perceived key role in the metabolism of inorganic arsenic. Recent work, however, has suggested that ...
Britta Fängström, Sophie E. Moore, Barbro Nermell, Linda Kuenstl et al.
BACKGROUND: Chronic arsenic exposure causes a wide range of health effects, but little is known about critical windows of exposure. Arsenic readily crosses the placenta, but the few available data on postnatal exposure to arsenic via breast milk are not conclusive. AIM: Our goal was to assess the ar...
Maria Kippler, Eva‐Charlotte Ekström, Bo Lönnerdal, Walter Goessler et al.
Cadmium is a widespread environmental contaminant present in food. The absorption in the intestine increases in individuals with low iron stores, but the effect of zinc deficiency is not clear. The aim of the present study was to assess the influence of iron and zinc status on cadmium accumulation i...
Li Li, Eva‐Charlotte Ekström, Walter Goessler, Bo Lönnerdal et al.
BACKGROUND: The interindividual variation in metabolism of inorganic arsenic (iAs), involving methylation via one-carbon metabolism, has been well documented, but the reasons remain unclear. OBJECTIVES: In this population-based study we aimed to elucidate the effect of nutrition on As methylation am...
Maria Kippler, Walter Goessler, Barbro Nermell, Eva‐Charlotte Ekström et al.
Experimental studies indicate that zinc (Zn) and calcium (Ca) status, in addition to iron (Fe) status, affect gastrointestinal absorption of cadmium (Cd), an environmental pollutant that is toxic to kidneys, bone and endocrine systems. The aim of this study was to evaluate how various nutritional fa...
Maria Kippler, Bo Lönnerdal, Walter Goessler, Eva-Charlotte Ekström et al.
Although the concentrations of the toxic metal cadmium in breast milk are generally low (< 1 microg/L), experimental studies indicated neurobehavioral and endocrine effects in the suckling offspring. The aim of the present study was to elucidate how cadmium is transported to breast milk by assessing...
Karin Ljung, Maria Kippler, Walter Goessler, G. Margaretha Grandér et al.
Manganese exposure and biomarker concentrations during early pregnancy and lactation were investigated in 408 women living in an area with elevated concentrations of both arsenic and manganese in drinking water derived from wells. About 40% of the water samples had manganese concentrations above the...
Lindsay Avolio, Tyler Smith, Ana Navas‐Acién, Kate Kruczynski et al.
BACKGROUND: Arsenic exposure and micronutrient deficiencies may alter immune reactivity to influenza vaccination in pregnant women, transplacental transfer of maternal antibodies to the foetus, and maternal and infant acute morbidity. OBJECTIVES: The Pregnancy, Arsenic, and Immune Response (PAIR) St...
Tyler Smith, Ana Navas‐Acién, Sarah Baker, Caryn Kok et al.
INTRODUCTION: Arsenic methylation converts inorganic arsenic (iAs) to monomethyl (MMA) and dimethyl (DMA) arsenic compounds. Body mass index (BMI) has been positively associated with arsenic methylation efficiency (higher DMA%) in adults, but evidence in pregnancy is inconsistent. We estimated assoc...
Lindsay Avolio, Tyler Smith, Ana Navas‐Acién, Kate Kruczynski et al.
ABSTRACT Purpose Arsenic exposure and micronutrient deficiencies may alter immune reactivity to influenza vaccination in pregnant women, transplacental transfer of maternal antibodies to the fetus, and maternal and infant acute morbidity. The Pregnancy, Arsenic, and Immune Response (PAIR) Study is a...
Tyler Smith, Lindsay Avolio, Ana Navas Acien, Walter Goessler et al.
BACKGROUND AND AIM: Arsenic methylation—the conversion of inorganic arsenic (iAs) to less toxic monomethyl (MMA) and dimethyl (DMA) species—could modify the developmental and reproductive toxicity of this metalloid. However, variability in arsenic methylation among pregnant women remains poorly unde...
Anna‐Lena Lindberg, Walter Goessler, Giovanni Leonardi, Mahfuzar Rahman et al.