Chowdhury Rafeed Rahman, Preetom S. Arko, Mohammed Eunus Ali, Mohammad Ashik Iqbal Khan et al.
Accurate and timely detection of diseases and pests in rice plants can help farmers in applying timely treatment on the plants and thereby can reduce the economic losses substantially. Recent developments in deep learning-based convolutional neural networks (CNN) have greatly improved image classifi...
Shannon Takala‐Harrison, Christopher G. Jacob, Cesar Arze, Michael P. Cummings et al.
BACKGROUND: The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia. METHODS: P. fal...
Sabeena Ahmed, Mohammad Mahbubul Karim, Allen G. Ross, Mohammad Hossain et al.
Ivermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. A randomized, double-blind, placebo-controlled trial was conducted to determine the rapidity of viral clearance and saf...
Nga Thi Thuy, Huong T L Vu, Chuc T K Nguyen, Sureeporn Punpuing et al.
BACKGROUND: Antimicrobial misuse is common in low-income and middle-income countries (LMICs), and this practice is a driver of antibiotic resistance. We compared community-based antibiotic access and use practices across communities in LMICs to identify contextually specific targets for intervention...
Md. Enamul Huq, Shah Fahad, Zhenfeng Shao, Most. Sinthia Sarven et al.
Groundwater with an excessive level of Arsenic (As) is a threat to human health. In Bangladesh, out of 64 districts, the groundwater of 50 and 59 districts contains As exceeding the Bangladesh (50 μg/L) and WHO (10 μg/L) standards for potable water. This review focuses on the occurrence, origin, pla...
Wasif Ali Khan, Carlos Seas, Ujjwal Dhar, Mohammed Abdus Salam et al.
BACKGROUND: Treatment of shigellosis is currently limited by the high prevalence of multidrug-resistant strains of Shigella. OBJECTIVE: To determine the efficacy of azithromycin in the treatment of shigellosis. DESIGN: Randomized, double-blind clinical trial. SETTING: Diarrhea treatment center in Dh...
Debasish Saha, Mohammad Mahbubul Karim, Wasif Ali Khan, Sabeena Ahmed et al.
BACKGROUND: Single-dose azithromycin is effective in the treatment of severe cholera in children, but its effectiveness in adults has not been evaluated. METHODS: We conducted a double-blind, randomized trial comparing the equivalence of azithromycin and ciprofloxacin (each given in a single 1-g dos...
Joseph A. Lewnard, Esmita Charani, Alec Gleason, Li Yang Hsu et al.
National action plans enumerate many interventions as potential strategies to reduce the burden of bacterial antimicrobial resistance (AMR). However, knowledge of the benefits achievable by specific approaches is needed to inform policy making, especially in low-income and middle-income countries (L...
Hajo Grundmann, Keith P. Klugman, Timothy R. Walsh, Pilar Ramón-Pardo et al.
The foreseen decline in antibiotic effectiveness explains the needs for data to inform the global public health agenda about the magnitude and evolution of antibiotic resistance as a serious threat to human health and development. Opportunistic bacterial pathogens are the cause of the majority of co...
Wasif Ali Khan, Jeffrey K. Griffiths, Michael L. Bennish
OBJECTIVE: To determine the clinical manifestations and outcome of shigellosis among children infected with different species of Shigella. METHODS: We identified all patients <15 years infected with Shigella admitted to the icddr, b Dhaka hospital during one year. Study staff reviewed admission reco...
Michael L. Bennish, Mohammed Abdus Salam, Wasif Ali Khan, Ali Miraj Khan
OBJECTIVE: To determine whether a single dose, or 2 doses, of ciprofloxacin are as effective as 5-day, 10-dose therapy for the treatment of shigellosis in adult men who are moderately to severely ill. DESIGN: Randomized, double-blind clinical trial. SETTING: A diarrhea treatment center in the capita...
Robert J. Commons, J. A. Simpson, Kamala Thriemer, Georgina Humphreys et al.
BACKGROUND: Chloroquine remains the mainstay of treatment for Plasmodium vivax malaria despite increasing reports of treatment failure. We did a systematic review and meta-analysis to investigate the effect of chloroquine dose and the addition of primaquine on the risk of recurrent vivax malaria acr...
Barbara Stefañska, David Cheishvili, Matthew Suderman, Ani Arakelian et al.
PURPOSE: We utilized whole-genome mapping of promoters that are activated by DNA hypomethylation in hepatocellular carcinoma (HCC) clinical samples to shortlist novel targets for anticancer therapeutics. We provide a proof of principle of this approach by testing six genes short-listed in our screen...
Peter Kim Streatfield, Wasif Ali Khan, Abbas Bhuiya, Nurul Alam et al.
BACKGROUND: Because most deaths in Africa and Asia are not well documented, estimates of mortality are often made using scanty data. The INDEPTH Network works to alleviate this problem by collating detailed individual data from defined Health and Demographic Surveillance sites. By registering all de...
Hong Bin Kim, Minghua Wang, Sabeena Ahmed, Chi Hye Park et al.
Ciprofloxacin was introduced for treatment of patients with cholera in Bangladesh because of resistance to other agents, but its utility has been compromised by the decreasing ciprofloxacin susceptibility of Vibrio cholerae over time. We correlated levels of susceptibility and temporal patterns with...