Weidong Qin, Wen‐Wu Bai, Keyin Liu, Ya Liu et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in December 2019 and rapidly spread to other provinces in China as well as other countries. In this study, 262 patients diagnosed with moderate to severe SARS-CoV-2 pneumonia in Wuhan, China, were analyzed. Data were compared bet...
Wen‐Wu Bai, Tao Guo, Han Wang, Bin Li et al.
Abstract Collateral circulation is essential for blood resupply to the ischemic heart, which is dictated by the contractile phenotypic restoration of vascular smooth muscle cells (VSMC). Here we investigate whether S-nitrosylation of AMP-activated protein kinase (AMPK), a key regulator of the VSMC p...
Xueqing Wang, Sen Yin, Qianwen Wang, Wen‐Wu Bai et al.
Angiogenesis contributes to heart functional recovery after acute myocardial infraction (AMI). We have previously reported that sublimation of vitamin B6 (VB6) prevents multiple cardiovascular diseases. Whether VB6 promotes angiogenesis to prevent cardiac dysfunction following AMI remains unknown. A...
Zhipeng Song, Chen Lin, Qianwen Wang, Zhenshan Zhang et al.
The integrity of the endothelial monolayer is critical for preventing life-threatening hemorrhaging and thrombosis. However, how severe endothelium-denuded injury is rapidly repaired remains unknown. Given the common biological properties between endothelial cells and circulating monocytes, we aimed...
Xuefei Dong, Xue-Jiao Jing, Zhen-yu Tang, Sheng-lan Huang et al.
The best way of treating vasospastic angina pharmacologically is to induce vasorelaxation under hypoxia only. We previously established a new method to quantify the contraction and relaxation of vascular smooth muscle cells (VSMCs) in real time. In the present study, we used this method to screen th...