Armand Van Deun, K. J. M. Aung, Valentin Bola, Rossin Lebeke et al.
The rapid diagnosis of rifampin resistance is hampered by a reported insufficient specificity of molecular techniques for detection of rpoB mutations. Our objective for this study was to document the prevalence and prognostic value of rpoB mutations with unclear phenotypic resistance. The study si...
Leen Rigouts, Nele Coeck, Mourad Gumusboga, Willem Bram de Rijk et al.
OBJECTIVES: Mutations in the gyrase genes cause fluoroquinolone resistance in Mycobacterium tuberculosis. However, the predictive value of these markers for clinical outcomes in patients with MDR-TB is unknown to date. The objective of this study was to determine molecular markers and breakpoints pr...
Armand Van Deun, Tom Decroo, K. J. M. Aung, M. Anwar Hossain et al.
<b>Despite their name, borderline <i>rpoB</i> mutations are correlated with unfavourable outcomes when rifampicin-throughout treatment is used. They may become the drivers of rifampicin-resistant tuberculosis. Second-line treatment is recommended.</b> https://bit.ly/3nbkZjt
Isabel Cuella Martin, Wim Mulders, Jelle Keysers, François Hakizayezu et al.
Abstract Background In Rwanda, genomic surveillance identified a dominant multidrug-resistant tuberculosis (MDR-TB) strain, the R3clone, responsible for approximately 70% of rifampicin-resistant TB cases. Its presence beyond Rwanda remains unexplored. Methods Unique genetic signatures of the R3clone...