CARDIoGRAMplusC4D, Joanna M. M. Howson, EPIC-CVD, Wei Zhao et al.
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may...
Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung‐Jin Lee et al.
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D...
Gilles R. Dagenais, Hertzel C. Gerstein, Xiaohe Zhang, Matthew McQueen et al.
OBJECTIVE: The goal of this study was to assess whether diabetes prevalence varies by countries at different economic levels and whether this can be explained by known risk factors. RESEARCH DESIGN AND METHODS: The prevalence of diabetes, defined as self-reported or fasting glycemia ≥7 mmol/L, was d...
Xiuling Tian, Weie Wen, Li Xie, Luping Fu et al.
Height is an important trait related to plant architecture and yield potential in bread wheat (Triticum aestivum L.). We previously identified a major quantitative trait locus (QTL) QPH.caas-6A flanked by simple sequence repeat markers Xbarc103 and Xwmc256 that reduced height by 8.0–10.4%. Here QPH....
Meiling Su, Chaofei Chen, Shaoying Li, Musheng Li et al.
Platelets have emerged as key inflammatory cells implicated in the pathology of sepsis, but their contributions to rapid clinical deterioration and dysregulated inflammation have not been defined. Here, we show that the incidence of thrombocytopathy and inflammatory cytokine release was significantl...
Xiaoru Chang, Xiujuan Wang, Jiangyan Li, Mengting Shang et al.
With the widespread application and inevitable environmental exposure, silver nanoparticles (AgNPs) can be accumulated in various organs. More serious concerns are raised on the biological safety and potential toxicity of AgNPs in the central nervous system (CNS), especially in the hippocampus. This...
Jingyuan Li, Li Gong, Shaozhuang Liu, Yujie Zhang et al.
Abstract Human antigen R (HuR) is a member of the Hu family of RNA-binding proteins and is involved in many physiological processes. Obesity, as a worldwide healthcare problem, has attracted more and more attention. To investigate the role of adipose HuR, we generate adipose-specific HuR knockout (H...
Harun-Or-Roshid, Wen‐Xiu Ma
To explore the features of lump solutions, which are local in every direction of space, a ( 2 + 1 )-dimensional extended shallow water wave model is studied, based on its bilinear representation. Several ansatzes have been utilized to determine single lump waves, lump-kink waves, single kinks and mu...
Guiyao Xiong, Guangquan Chen, Xingyong Xu, Wenquan Liu et al.
In recent years, Thailand and Bangladesh have been drawing more attention due to groundwater pollution, but there is rarely a comparative study on hydrochemical evolution and quality assessment of groundwater in the areas In this paper, end-member mixing and Gibbs model are used to study the evoluti...
Shanshan Liu, Xiuxin Jiang, Xiuru Cui, Jingjing Wang et al.
Abstract Human antigen R (HuR) is a widespread RNA-binding protein involved in homeostatic regulation and pathological processes in many diseases. Atherosclerosis is the leading cause of cardiovascular disease and acute cardiovascular events. However, the role of HuR in atherosclerosis remains unkno...
Mohammad Safi Ullah, Harun-Or Roshid, Wen‐Xiu Ma, Md Zulfikar Ali et al.
In this article, we consider a (3 + 1)-dimensional Sharma–Tasso–Olver-like (STOL) model describing dynamical propagation of nonlinear dispersive waves in inhomogeneous media. Applying Hirota's bilinear technique and a trial function, we explore nonlinear dynamical properties of basic solutions to th...
Dachang Bai, Xiuli Guo, Xinghua Wang, Wenjie Xu et al.
Abstract Umpolung is an old and important concept in organic chemistry, which significantly expands the chemical space and provides unique structures. While, previous research focused on carbonyls or imine derivatives, the umpolung reactivity of polarized C–C σ-bonds still needs to explore. Herein, ...
Hanlin Lu, Peidong Yuan, Xiaoping Ma, Xiuxin Jiang et al.
Angiogenesis is a critical pathophysiological process involved in organ growth and various diseases. Transcription factors Sp1/Sp3 are necessary for fetal development and tumor growth. Sp1/Sp3 proteins were downregulated in the capillaries of the gastrocnemius in patients with critical limb ischemia...
Xiu Liu, Wenyi Dong, Shaohui Jia, Qian Liu et al.
Md Nur Hossain, M. Mamun Miah, Abdul Hamid Ganie, M.S. Osman et al.
Chaoyue Zhang, Guo Wen Sun, Yun Bai, Zhe Dai et al.
A new type of vanadium sulfide (V<sub>2</sub>S<sub>3</sub>) was used for high-performance lithium–sulfur batteries.
Yangbo Ma, Liang Guo, Liang Chang, Weihua Guo et al.
Tandem catalysis is an effective approach to achieve highly selective and high-rate multi-electron/proton transfer reactions, such as nitrate electroreduction, which are important for various physicochemical and biological processes. However, present tandem catalysts suffer from uncontrollable inter...
Md Elias Hossain, Xurong Mei, Wenying Zhang, Wenyi Dong et al.
The impact of chemical to organic fertilizer substitution on soil labile organic and stabilized N pools under intensive farming systems is unclear. Therefore, we analyzed the distribution of soil total N (STN), particulate organic N (PON), microbial biomass N (MBN), dissolved organic N (DON), and mi...
Noor Alam, Wen‐Xiu Ma, Mohammad Safi Ullah, Aly R. Seadawy et al.
In this research, the modified extended tanh-function (METF) and the extended Jacobi elliptic function expansion (EJEFE) techniques are used to investigate the generation and detection of soliton structures in the Hirota–Maccari (HM) model. Consequently, we obtain soliton solutions with advanced str...
Wen Xiong Huang, Tianhua Jiang, Xiucheng Zhang, Naveed Ahmad Khan et al.
Design problems in structural engineering are often modeled as differential equations. These problems are posed as initial or boundary value problems with several possible variations in structural designs. In this paper, we have derived a mathematical model that represents different structures of be...