Yasuhito Tanaka, Izumi Hasegawa, Takanobu Kato, Etsuro Orito et al.
There are two subtypes of hepatitis B virus genotype A (HBV/A) and they are provisionally designated Aa ("a" standing for Africa/Asia) and Ae ("e" for Europe). In a case-control study, 78 HBV/Aa, 78HBV/Ae, and 78HBV/D carriers from several countries were compared. The prevalence of HBe antigen (HBeA...
Fuminaka Sugauchi, Hiromitsu Kumada, Subrat A. Acharya, Santosh Man Shrestha et al.
Complete nucleotide sequences of 19 hepatitis B virus (HBV) isolates of genotype A (HBV/A) were determined and analysed along with those of 20 previously reported HBV/A isolates. Of the 19 HBV/A isolates, six including three from Japan and three from the USA clustered with the 14 HBV/A isolates from...
M.A. Mazid, Yasuhito Tanaka, Teruhisa KATAYAMA, Mamunur Rahman et al.
Mohammad Enamul Hoque Kayesh, Yutaka Amako, Md Abul Hashem, Shuko Murakami et al.
Chronic hepatitis B virus (HBV) infection constitutes a global health issue with limited current therapeutic efficacy owing to the persistence of viral episomal DNA (cccDNA). The CRISPR/Cas9 system, a newly developed, powerful tool for genome editing and potential gene therapy, requires efficient de...
Karima Abounouh, Mohammad Enamul Hoque Kayesh, Haya Altawalah, Bouchra Kitab et al.
Background Hepatitis B Virus (HBV) is the most common cause of chronic liver disease worldwide. The mechanisms that regulate HBV viral replication remain poorly defined. Here, we show that blocking of the neddylation elicits antiviral effect against HBV replication, indicating that NEDD8 supports vi...
Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Takahiro Sanada, Bouchra Kitab et al.
Hepatitis B virus (HBV) infection is a global public health problem. The clinical outcomes of HBV infections are influenced by host as well as viral factors, including viral genotypes and subgenotypes. The interplay between HBV and host innate immunity remains unclear because of the lack of a suitab...
Rupaly Akhter, Bouchra Kitab, Mohammad Enamul Hoque Kayesh, Rina Shimizu et al.
Patients with chronic hepatitis B virus (HBV) infection may benefit from clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-based gene therapy. We previously identified a guide RNA (WJ11) that suppressed HBV replication in vitro and in vivo; however...