Michio Hashimoto, Masanori Katakura, Yoko Tanabe, Abdullah Al Mamun et al.
We investigated whether a highly purified eicosapentaenoic acid (EPA) and a concentrated n-3 fatty acid formulation (prescription TAK-085) containing EPA and docosahexaenoic acid (DHA) ethyl ester could improve the learning ability of aged rats and whether this specific outcome had any relation with...
Michio Hashimoto, Hossain Md Shahdat, Shinji Yamashita, Masanori Katakura et al.
We have previously reported that dietary docosahexaenoic acid (DHA) improves and/or protects against impairment of cognition ability in amyloid beta(1-40) (Abeta(1-40))-infused Alzheimer's disease (AD)-model rats. Here, after the administration of DHA to AD model rats for 12 weeks, the levels of Abe...
Hiroshi Yokota, K. TANABE, Mitsuhiro SEZAKI, Yasuhiro Akiyoshi et al.
Michio Hashimoto, Setsushi Kato, Yoko Tanabe, Masanori Katakura et al.
AIM: We examined the effects of the administration of docosahexaenoic acid (DHA)-enriched meals on cognitive function in the oldest elderly with cognitive impairment, such as dementia, living in nursing homes, and on the improvement in caregiver burden at aging agencies. METHODS: Participants in eld...
Michio Hashimoto, Hossain Md Shahdat, Masanori Katakura, Yoko Tanabe et al.
Amyloid beta peptide(25-35) (Abeta(25-35)) encompasses one of the neurotoxic domains of full length Abeta(1-40/42), the major proteinaceous component of amyloid deposits in Alzheimer's disease (AD). We investigated the effect of docosahexaenoic acid (DHA, 22:6, n-3), an essential brain polyunsaturat...
Kimiko Tanabe, Hiroshi Yokota, Hiromi Hironaka, Sachie Tsushima et al.
Abstract Arsenic concentrations in groundwater around the village of Samta, Jessore District, Bangladesh were measured. Distribution patterns of arsenic in groundwater were determined. Arsenic concentrations in drinking water tubewells mostly exceeded WHO guidelines. Copyright © 2001 John Wiley &...
Michio Hashimoto, Yoko Tanabe, Shahdat Hossain, Kentaro Matsuzaki et al.
Oxidized low-density lipoprotein (Ox-LDL) is known to be highly atherogenic. Thus, decreasing the blood levels of Ox-LDL through dietary means is an important approach to reduce cardiovascular events in high-risk individuals. In this randomized placebo-controlled human interventional trial, we aimed...
Michio Hashimoto, Kentaro Matsuzaki, Shahdat Hossain, Tomoko Ito et al.
seed oil (PO), a rich source of α-linolenic acid (LNA, C18:3, ω-3), helps in maintaining good mental health in adults. This study aimed to investigate the impacts of dietary PO intake on cognitive functions and mental health in healthy, elderly Japanese individuals. Seventy-five healthy volunteers a...
Michio Hashimoto, Kentaro Matsuzaki, Koji Maruyama, Shahdat Hossain et al.
) seed oil (PO), rich in α-linolenic acid (ALA), can improve cognitive function in healthy elderly Japanese people. Here, supplements containing either PO alone or PO with nobiletin-rich air-dried immature ponkan powder were examined for their effects on cognitive function in 49 healthy elderly Japa...
Takashi Ichinose, Kentaro Matsuzaki, Masaharu Kato, Yoko Tanabe et al.
The pathogenic mechanism of dementia is still unknown, and the fundamental treatment remains to be established. Thus, there is growing interest in preventing dementia through diet. One of the functional ingredients attracting attention is docosahexaenoic acid. We conducted a 12-month, randomized, do...
Michio Hashimoto, Kentaro Matsuzaki, Koji Maruyama, Eri Sumiyoshi et al.
more effectively ameliorates age-related cognitive decline than PO alone. These findings may serve as a basis for the development of new supplements for brain health. Clinical Trial Registry, UMIN000040863.
Michio Hashimoto, Masanori Katakura, Toru Nabika, Yoko Tanabe et al.
BACKGROUND: Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome...
Hiroshi Yokota, K. TANABE, Mitsuhiro SEZAKI, Yuto Yano et al.
In March 1997, we analyzed the water of all tubewells used for drinking in Samta village in the Jessore district, Bangladesh. It has been confirmed from the survey that the arsenic contamination in Samta was one of the worst in the Ganges basin including West Bengal, India. 90% of the tubewells had ...
Takashi Ichinose, Masaharu Kato, Kentaro Matsuzaki, Yoko Tanabe et al.
Recent approaches to the management of dementia have focused mainly on continual preventive treatment. In this study, we investigated whether intake of 297 mg docosahexaenoic acid (DHA) and 137 mg eicosapentaenoic acid (EPA) per day, which is a smaller amount than in previous reports, would maintain...
Kentaro Matsuzaki, Shahdat Hossain, Harumi Wakatsuki, Yoko Tanabe et al.
Accumulating evidence suggests the beneficial effect of omega-3 polyunsaturated fatty acids (PUFAs) on bone mineral density (BMD). However, the effects of perilla (Perilla frutescens) seed oil (PO), a rich source of α-linoleic acid (LNA), on human bone have not yet been elucidated. This randomized, ...
Eri Sumiyoshi, Michio Hashimoto, Shahdat Hossain, Kentaro Matsuzaki et al.
Learning and memory impairment may result from age-related decline in synaptic plasticity-related proteins in the hippocampus. Therefore, exploration of functional foods capable of ameliorating memory and cognition decline is an interesting endeavor in neuroscience research. We report the effects of...
Michio Hashimoto, Takayuki Inoue, Masanori Katakura, Yoko Tanabe et al.
Metabolic syndrome is implicated in the decline of cognitive ability. We investigated whether the prescription n-3 fatty acid administration improves cognitive learning ability in SHR.Cg-Lepr(cp)/NDmcr (SHR-cp) rats, a metabolic syndrome model, in comparison with administration of eicosapentaenoic a...
Michio Hashimoto, Shahdat Hossain, Yoko Tanabe, Osamu Shido
Age-related changes in adenyl purine release from rat arteries and endothelial cell (EC) plasma membrane (PM) fluidity were studied. High performance liquid chromatography-fluorescence revealed that aging significantly decreased the release of adenyl purines. Pyrene-excimer spectroscopy disclosed th...
Shahdat Hossain, Jakir Hussain, Sujan Bhowmick, Marzan Sarkar et al.
Docosahexaenoic acid (DHA, C22:6, ω-3), an ω-3 polyunsaturated fatty acid (PUFA), is critical for brain growth, development, and cognitive ability. It is consumed by offspring via milk during lactation. However, the toxic heavy metal lead (Pb) readily passes into the mammary glands of mother animals...
Abdullah Al Mamun, Michio Hashimoto, Masanori Katakura, Yoko Tanabe et al.
The effects of cholesterol-lowering statins, which substantially benefit future cardiovascular events, on fatty acid metabolism have remained largely obscured. In this study, we investigated the effects of atorvastatin on fatty acid metabolism together with the effects of TAK-085 containing highly p...