Feng Bai, Ni Shu, Yonggui Yuan, Yongmei Shi et al.
Alzheimer's disease (AD) can be conceptualized as a disconnection syndrome. Both remitted geriatric depression (RGD) and amnestic mild cognitive impairment (aMCI) are associated with a high risk for developing AD. However, little is known about the similarities and differences in the topological pat...
Yuan Zhang, Rongrong Huang, Mengjing Cheng, Lirui Wang et al.
BACKGROUND: Inflammasomes have been found to interact with the gut microbiota, and this effect is associated with depression, but the mechanisms underlying this interaction have not been elucidated in detail. RESULTS: The locomotor activity of NLRP3 KO mice was significantly greater than that of the...
Nan Jiang, Zhijun Guo, Dan Sun, Yubao Li et al.
In this study, micro/nanoscaled hierarchical hybrid coatings containing titanium (Ti) phosphate and Ti oxide have been fabricated with the aim of promoting osseointegration of Ti-based implants. Three representative surface coatings, namely, micro/nanograss Ti (P-G-Ti), micro/nanoclump Ti, (P-C-Ti),...
Youyong Kong, Shuwen Gao, Yingying Yue, Zhenhua Hou et al.
The pathophysiology of major depressive disorder (MDD) has been explored to be highly associated with the dysfunctional integration of brain networks. It is therefore imperative to explore neuroimaging biomarkers to aid diagnosis and treatment. In this study, we developed a spatiotemporal graph conv...
Yonggui Yuan, Zhijun Zhang, Feng Bai, Hui Yu et al.
Previous studies have demonstrated lower-diffusion anisotropy within white matter in late-onset depression measured by diffusion tensor imaging, which provides information about brain white matter integrity. We have examined whether white matter is abnormal in first-episode remitted geriatric depres...
Zan Wang, Yonggui Yuan, Feng Bai, Hao Shu et al.
The regional specificity of hippocampal abnormalities in late-life depression (LLD) has been demonstrated in previous studies. In this study, we sought to examine the functional connectivity (FC) patterns of hippocampal subregions in remitted late-onset depression (rLOD), a special subtype of LLD. F...
Wei Liu, Yuexia Sun, Ningrui Liu, Jing Hou et al.
China's profoundly rapid modernization in the past two decades has resulted in dramatic changes in indoor environmental exposures. Among these changes, exposure to phthalates has attracted increasing attention. We aimed to characterize indoor phthalate exposure and to estimate the disease burden att...
Jiao Jiao, Jinjian Huang, Zhijun Zhang
ABSTRACT The repair of tissue defects after injury is of significant clinical and research importance. A variety of chitosan‐based hydrogels have been investigated and applied to address this problem. By using different synthetic methods, the hydrogels exhibit distinct physical properties, including...
Zhijun Guo, Nan Jiang, Jessica Moore, Colin P. McCoy et al.
Through a nature-inspired layer-by-layer assembly process, we developed a unique multifunctional tissue scaffold that consists of porous polyurethane substrate and nanoscale chitosan/graphene oxide hybrid coating. Alternative layers of drug-laden chitosan and graphene oxide nanosheets were held toge...
Hui Xu, Xiaohong Li, Jingwei Zhang, Zhijun Zhang et al.
Zhiwei Li, Bing Shao, Yong‐Shan Huang, Xiaohong Li et al.
Macromolecule flame retardant melamine‐dicyandiamide‐formaldehyde‐phosphoric acid (denoted as MDFP) was used as the shell material to synthesize zinc hydroxystannate@MDFP (denoted as ZHS@MDFP), a novel composite flame retardant with core–shell structure, via masterbatch method. The morphology and st...
Feng Bai, Wei Liao, Chunxian Yue, Mengjia Pu et al.
The tau hypothesis has been raised with regard to the pathophysiology of Alzheimer's disease (AD). Mild cognitive impairment (MCI) is associated with a high risk for developing AD. However, no study has directly examined the brain topological alterations based on combined effects of tau protein path...
Yuxiu Sui, Zhijun Zhang, Yijing Guo, Yi Eve Sun et al.
Chronic fluoxetine administration can increase neurogenesis in the adult hippocampus, but the molecular mechanisms remain unclear. The Notch1 signaling pathway is expressed highly in the hippocampus and could be a target for diverse environmental modulators of adult neurogenesis. This prompted us to...
Sha Liu, Xuan Liu, Yefan Duan, Li Huang et al.
The precision magnetic stimulation system (pMSS), mediated by superparamagnetic iron oxide nanoparticles (SPIONs), can modulate endogenous oxytocin secretion by targeting the paraventricular nucleus (PVN) and improve autistic-like behavior in mice. In this study, the underlying mechanisms of this sy...
Qijie Xu, Xiaohong Li, Zhijun Zhang