Se Eun Park, Duy Pham Thanh, Christine J. Boinett, Vanessa Wong et al.
There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 s...
Megan E. Carey, Zoe A. Dyson, Danielle J. Ingle, Afreenish Amir et al.
Background: serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which marks 22 years since the publication of the first Typhi genome, represents the largest Typhi genome sequence collection to date (n=13,000). Methods: This is a meta-analysis of global genotype and anti...
Késia Esther da Silva, Arif Mohammad Tanmoy, Agila Kumari Pragasam, Junaid Iqbal et al.
BACKGROUND: The emergence of increasingly antimicrobial-resistant Salmonella enterica serovar Typhi (S Typhi) threatens to undermine effective treatment and control. Understanding where antimicrobial resistance in S Typhi is emerging and spreading is crucial towards formulating effective control str...
Danielle J. Ingle, Satheesh Nair, Hassan Hartman, Philip Ashton et al.
Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever, a systemic human infection with a burden exceeding 20 million cases each year that occurs disproportionately among children in low and middle income countries. Antimicrobial therapy is the mainstay for treatment, b...
Megan E. Carey, Ruby Jain, M. Yousuf, Mailis Maes et al.
BACKGROUND: The emergence and spread of antimicrobial resistance (AMR) pose a major threat to the effective treatment and control of typhoid fever. The ongoing outbreak of extensively drug-resistant Salmonella Typhi (S. Typhi) in Pakistan has left azithromycin as the only remaining broadly efficacio...
Sadia Rahman, Zoe A. Dyson, Elizabeth J. Klemm, Farhana Khanam et al.
BACKGROUND: Multi-drug resistant typhoid fever remains an enormous public health threat in low and middle-income countries. However, we still lack a detailed understanding of the epidemiology and genomics of S. Typhi in many regions. Here we have undertaken a detailed genomic analysis of typhoid in ...
Samuel Kariuki, Zoe A. Dyson, Cecilia Mbae, Ronald Ngetich et al.
Background: Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control. Methods: In a 3-year case-control study, we investigated typhoid among children aged <16 years (4670 febrile cases and 8549 age matched controls...
Junaid Iqbal, Irum Fatima Dehraj, Megan E. Carey, Zoe A. Dyson et al.
The emergence of XDR Salmonella Typhi in Pakistan has left azithromycin as the only viable oral treatment option. Here, we report the detection of an azithromycin resistance-associated mutation in one S. Typhi isolate. This finding is important because any possible spread of azithromycin resistance ...
Arif Mohammad Tanmoy, Yogesh Hooda, Mohammad Saiful Islam Sajib, Kesia E. da Silva et al.
Salmonella Paratyphi A, the primary etiology of paratyphoid, is estimated to cause 3.4 million infections annually, worldwide. With rising antimicrobial resistance and no licensed vaccines, genomic surveillance is key to track and monitor transmission, but there is currently no reliable genotyping f...
Sadia Rahman, To Nguyen Thi Nguyen, Farhana Khanam, Nicholas R. Thomson et al.
BACKGROUND: The proportion of enteric fever cases caused by Salmonella Paratyphi A is increasing and may increase further as we begin to introduce typhoid conjugate vaccines (TCVs). While numerous epidemiological and genomic studies have been conducted for S. Typhi, there are limited data describing...
Zoe A. Dyson, Philip Ashton, Farhana Khanam, Angeziwa Chunga Chirambo et al.
BACKGROUND: Enteric fever is a serious public health concern. The causative agents, Salmonella enterica serovars Typhi and Paratyphi A, frequently have antimicrobial resistance (AMR), leading to limited treatment options and poorer clinical outcomes. We investigated the genomic epidemiology, resista...
Samuel Kariuki, Zoe A. Dyson, Cecilia Mbae, Ronald Ngetich et al.
Abstract Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control. In a 3 year case-control study, we investigated typhoid among children aged <16 years (4,670 febrile cases and 8,549 age matched controls) livin...
Zoe A. Dyson, Philip Ashton, Farhana Khanam, Angeziwa Chunga et al.
Abstract Background Enteric fever is a serious public health concern. The causative agents, Salmonella enterica serovars Typhi and Paratyphi A, are frequently antimicrobial resistant (AMR), leading to limited treatment options and poorer clinical outcomes. We investigated the genomic epidemiology, r...
Danielle J. Ingle, Jane Hawkey, Martin Hunt, Zamin Iqbal et al.
Background: serovar Typhi (Typhi) and causes 10 million illnesses annually. Disease control relies on prevention (water, sanitation, and hygiene interventions or vaccination) and effective antimicrobial treatment. Antimicrobial resistant (AMR) Typhi lineages have emerged and become established in ma...
Arif Mohammad Tanmoy, Yogesh Hooda, Mohammad Saiful Islam Sajib, Kesia E. da Silva et al.
Abstract Background Salmonella enterica serovar Paratyphi A ( Salmonella Paratyphi A) is the primary causative agent of paratyphoid fever, which is responsible for an estimated 3.4 million infections annually. However, little genomic information is available on population structure, antimicrobial re...