Journal ArticleOpen Access
Genetic diversity of Plasmodium falciparum populations in southeast and western Myanmar
Authors
Than Naing Soe, Yanrui Wu, Myo Tun, Xin Xu, …
Author Affiliations
Ministry of Health and Sports, Department of Public Health, Kunming Medical University, Myanmar Oxford Clinical Research Unit, ...
Published InParasites & Vectors
Year2017
Citations44
Abstract
BACKGROUND: The genetic diversity of malaria parasites reflects the complexity and size of the parasite populations. This study was designed to explore the genetic diversity of Plasmodium falciparum populations collected from two southeastern areas (Shwekyin and Myawaddy bordering Thailand) and one western area (Kyauktaw bordering Bangladesh) of Myanmar. METHODS: A total of 267 blood samples collected from patients with acute P. falciparum infections during 2009 and 2010 were used for genotyping at the merozoite surface protein 1 (Msp1), Msp2 and glutamate-rich protein (Glurp) loci. RESULTS: One hundred and eighty four samples were successfully genotyped at three genes. The allelic distributions of the three genes were all significantly different among three areas. MAD20 and 3D7 were the most prevalent alleles in…
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