DNA damage and plasma antioxidant indices in Bangladeshi type 2 diabetic patients

Background and aim Diabetes mellitus is a complex metabolic disorder characterized by a disturbance in glucose metabolism. Recent evidence suggests that increased oxidative stress as well as alteration of antioxidant capacity may be related to the complications seen in patients with type 2 diabetes. The aim of this study was to measure serum antioxidant status in type 2 diabetic patients and to assess its relationship with oxidative DNA damage. Methods A total of 57 subjects were included in this study. Of these, 32 were type 2 diabetic patients and 25 were non-diabetic subjects. Comet assay was used to quantify the level of DNA damage in lymphocytes. Spectrophotometric methods were used to assess serum levels of malondialdehyde (MDA) and protein carbonyl,…