Journal ArticleUnknown
Improved specific loss power on cancer cells by hyperthermia and MRI contrast of hydrophilic Fe<sub>x</sub>Co<sub>1‐x</sub>Fe<sub>2</sub>O<sub>4</sub> nanoensembles
Authors
Author Affiliations
Yale University, Resonance Research (United States), Bangladesh Atomic Energy Commission, Michigan State University
Published InContrast Media & Molecular Imaging
Year2016
Citations25
Abstract
Ferrite‐based ferri/superparamagnetic nanoparticles can be rapidly heated by an external alternating magnetic field (AMF) to induce tissue necrosis of the adjacent microenvironment, but in addition provide magnetic resonance imaging (MRI) contrast utilizing enhanced water relaxivity. Here we characterized nanoensembles of Fe‐Co mixed spinel ferrites (i.e. Fe x Co 1‐x Fe 2 O 4 , where x ranges from 0.2 to 0.8) synthesized by chemical co‐precipitation. With nanoensembles of increasing Co content the saturation magnetization improved, while lattice parameter remained relatively constant. MRI water (transverse) relaxivity at 11.7 T was also boosted with increasing Co content. Efficiency of AMF‐induced heating was quite comparable for the nanoensembles with either chitosan or polyethylene glycol (PEG) coating except for PEG‐coated Fe 0.2 Co 0.8…
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Fields & Keywords
Physical SciencesMaterials ScienceBiomaterialsNanoparticle-Based Drug DeliveryMagnetic Properties and Synthesis of FerritesCharacterization and Applications of Magnetic NanoparticlesNuclear magnetic resonanceNuclear chemistryNanotechnologyMetallurgyComposite materialFinanceChromatographyBiotechnologyQuantum mechanics