Molecular activity of bioactive phytocompounds for inhibiting host cell attachment and membrane fusion interacting with West Nile Virus envelope glycoprotein

West Nile virus is an arbovirus primarily spread by mosquitoes, which are the principal carriers and belong to the Flaviviridae category. This widespread disease lacks specific treatments despite its potential lethality, urgently demanding novel pharmaceutical research and development aims to prevent severe or long-term complications and improve overall outcomes. Pandemic awareness, increasing global incidence, fatal illness effects, expenses associated with outbreaks, reducing suffering, and other broader implications highlight the study's wider significance. Drug design as a novel treatment approach to reduce the risk of resistance to the virus resulting from overuse of broad-spectrum antiviral therapies for unrelated viral diseases has been evaluated using computational techniques. Initially, molecular docking targeted the envelope glycoprotein of the WNV, utilizing a set of 5375…