Anti‐inflammatory, Antibacterial, Toxicological Profile, and <i>In Silico</i> Studies of Dimeric Naphthoquinones from <i>Diospyros lotus</i>

Diospyros lotus , also known as date‐plum, belongs to the Ebenaceae family and is mostly recognized as a rootstock for D . kaki . Similar classes of naphthoquinones in D . lotus are investigated against cancer and inflammation and have antimicrobial, sedative, and analgesic properties. Six chemical constituents (1‐6) were isolated from Diospyros lotus and tested for anti‐inflammatory effects at the dose of 2.5 and 5 mg/kg, i.p., using carrageenan (1%, 0.05 ml)‐induced paw edema. The maximum protection against carrageenan‐induced edema was observed for compounds 1 and 2. Both studied compounds demonstrated significant anti‐inflammatory effect after the 3 rd hour of posttreatment. The maximum anti‐inflammatory effect of compound 1 was 85.96%, while that of compound 2 was 81.44%, followed by…