Journal ArticleOpen Access
Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery
Authors
Author Affiliations
Queens University, Queen's University Belfast
Published InMolecular Pharmaceutics
Year2016
Citations161
Abstract
We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN arrays showed good mechanical properties. The system was loaded with up to 5% (w/w) ibuprofen included in a light-responsive 3,5-dimethoxybenzoin conjugate. Raman spectroscopy confirmed the presence of the conjugate inside the polymeric MN matrix. In vitro, this system was able to deliver up to three doses of 50 mg of ibuprofen upon application of an optical trigger over a prolonged period of time (up to 160 h). This makes the system appealing as…
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Fields & Keywords
Life SciencesPharmacology, Toxicology and PharmaceuticsPharmaceutical ScienceAdvancements in Transdermal Drug DeliveryDermatology and Skin DiseasesAdvanced Drug Delivery SystemsBiomedical engineeringNanotechnologyChemical engineeringPharmacologyComposite materialOrganic chemistryMathematical analysis