Duncan Q.M. Craig
Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. However, despite the publication of numerous original papers and reviews on the subject, the mechanisms ...
Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska et al.
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. ...
Quangang Zhu, Zhongjian Chen, Pijush Paul, Yi Lü et al.
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeut...
Sophia N. Economidou, Cristiane Patricia Pissinato Pere, Andrew Reid, Md Jasim Uddin et al.
3D printed microneedle arrays were fabricated using a biocompatible resin through stereolithography (SLA) for transdermal insulin delivery. Microneedles were built by polymerising consecutive layers of a photopolymeric resin. Thin layers of insulin and sugar alcohol or disaccharide carriers were for...
Md Jasim Uddin, Nicolaos Scoutaris, Sophia N. Economidou, Clementine Giraud et al.
In this study, novel 3D printed polymeric microneedle arrays were fabricated for enhanced cisplatin delivery to A-431 epidermoid skin tumours for cancer treatment. The microneedles were built by selectively photopolymerising consecutive layers of a biocompatible photopolymer resin using stereolithog...
Md Selim Reza, Quadir Ma, Syed Shabbir Haider
PURPOSE: The present study was undertaken to investigate the effect of plastic, hydrophilic and hydrophobic types of polymers and their content level on the release profile of drug from matrix systems. As the physico-chemical nature of the active ingredients influence the drug retarding ability of t...
Kumar Bishwajit Sutradhar, Md. Lutful Amin
Abstract Nanotechnology, the science of nano sized particles, has rapidly gained the spotlight in diversified areas including pharmaceutical sector. With the blessings of accurate drug designing and better pharmacological action, it has entered the pharmaceutical arena bringing promising discoveries...
Tasnuva Haque, Mesbah Talukder
Human skin could be a prime target to deliver drugs into the human body as it is the largest organ of human body. However, the main challenge of delivering drug into the skin is the stratum corneum (SC), the outer layer of epidermis, which performs the main barrier function of the skin. Scientists h...
John G. Hardy, Eneko Larrañeta, Ryan F. Donnelly, Niamh McGoldrick et al.
We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol d...
Sophia N. Economidou, Md Jasim Uddin, Manuel J. Marques, Dennis Douroumis et al.
The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and contr...
Neha Chauhan, Parul Vasava, Sharuk L. Khan, Falak A. Siddiqui et al.
Ethosomal systems are newer lipid vesicular carriers that have been around for 20 years, but over that period they have grown significantly as a means of transdermal drug delivery. They have a sizable amount of ethanol in them. These nanocarriers carry medicinal substances with various physicochemic...
Rafiqul Islam, Shihab Uddin, Md. Raihan Chowdhury, Rie Wakabayashi et al.
Since injection administration for diabetes is invasive, it is important to develop an effective transdermal method for insulin. However, transdermal delivery remains challenging owing to the strong barrier function of the stratum corneum (SC) of the skin. Here, we developed ionic liquid (IL)-in-oil...
Rafiqul Islam, Md. Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara et al.
Transdermal delivery of drugs is more challenging for drugs that are insoluble or sparingly soluble in water and most organic solvents. To overcome this problem, ionic liquid (IL)-mediated ternary systems have been suggested as potential drug carriers. Here, we report potent ternary (IL-EtOH-IPM) sy...
Rafiqul Islam, Md. Raihan Chowdhury, Rie Wakabayashi, Noriho Kamiya et al.
The transdermal delivery of sparingly soluble drugs is challenging due to of the need for a drug carrier. In the past few decades, ionic liquid (IL)-in-oil microemulsions (IL/O MEs) have been developed as potential carriers. By focusing on biocompatibility, we report on an IL/O ME that is designed t...
Kumar Bishwajit Sutradhar, Sabera Khatun, Irin Parven Luna
Nowadays, a very large proportion of new drug candidates emerging from drug discovery programmes are water insoluble and thus poorly bioavailable. To avoid this problem, nanotechnology for drug delivery has gained much interest as a way to improve the solubility problems. Nano refers to particles si...