ReviewUnknown
Molecular mechanisms of action of epigallocatechin gallate in cancer: Recent trends and advancement
Author Affiliations
Post Graduate Institute of Medical Education and Research, Green University of Bangladesh, Motilal Nehru National Institute of Technology, Lake Erie College of Osteopathic Medicine, ...
Published InSeminars in Cancer Biology
Year2020
Citations217
Abstract
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is an ester of epigallocatechin and gallic acid. EGCG, abundantly found in tea, is a polyphenolic flavonoid that has the potential to affect human health and disease. EGCG interacts with various recognized cellular targets and inhibits cancer cell proliferation by inducing apoptosis and cell cycle arrest. In addition, scientific evidence has illustrated the promising role of EGCG in inhibiting tumor cell metastasis and angiogenesis. It has also been found that EGCG may reverse drug resistance of cancer cells and could be a promising candidate for synergism studies. The prospective importance of EGCG in cancer treatment is owed to its natural origin, safety, and low cost which presents it as an attractive target for…
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