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A model of chlorpyrifos distribution and its biochemical effects on the liver and kidneys of rats
Authors
Author Affiliations
Gono University, Jahangirnagar University, Bangladesh Atomic Energy Commission, Universiti Sains Malaysia
Published InHuman & Experimental Toxicology
Year2015
Citations83
Abstract
This study investigated the main target sites of chlorpyrifos (CPF), its effect on biochemical indices, and the pathological changes observed in rat liver and kidney function using gas chromatography/mass spectrometry. Adult female Wistar rats (n = 12) were randomly assigned into two groups (one control and one test group; n = 6 each). The test group received CPF via oral gavage for 21 days at 5 mg/kg daily. The distribution of CPF was determined in various organs (liver, brain, heart, lung, kidney, ovary, adipose tissue, and skeletal muscle), urine and stool samples using GCMS. Approximately 6.18% of CPF was distributed in the body tissues, and the highest CPF concentration (3.80%) was found in adipose tissue. CPF also accumulated in the…
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