Journal ArticleOpen Access
Insights into the acute phase of Nipah virus infection: Clinical features, viral detection, and humoral immune response
Author Affiliations
International Centre for Diarrhoeal Disease Research, Institute of Epidemiology, Disease Control and Research, Centers for Disease Control and Prevention, University of Dhaka
Published InInternational Journal of Infectious Diseases
Year2025
Citations2
Abstract
OBJECTIVES: This study aimed to explore the humoral immune response and viral detection in the acute phase of Nipah virus (NiV) infection. METHODS: The study explored clinical and laboratory data from all 22 human NiV cases detected during the 2023, 2024 and 2025 outbreaks in Bangladesh. Oropharyngeal swabs and serum samples were tested for NiV genomic material by real-time reverse transcriptase polymerase chain reaction (RT-PCR); humoral immune response was detected by enzyme-linked immunosorbent assay (ELISA) for immunoglobulin M (IgM) and G (IgG). RESULTS: A majority of cases were male (64%), and the overall median age of all cases was 21 (0-70) years. The case fatality rate (CFR) was 86% (19/22). 18 (82%) of the cases had evidence of primary infection…
View at Publisher
BORR does not host full-text PDFs. The button above takes you to the original publisher.