Journal ArticleUnknown
A polymer-film inertial microfluidic sorter fabricated by jigsaw puzzle method for precise size-based cell separation
Authors
Zhixian Zhu, Dan Wu, Shuang Li, Han Yu, …
Author Affiliations
Southeast University, Jiangyin People's Hospital, Nanjing Medical University, Zhongda Hospital Southeast University
Published InAnalytica Chimica Acta
Year2020
Citations60
Abstract
A polymer-film inertial microfluidic jigsaw (PIMJ) sorter with trapezoidal spiral channels using the jigsaw puzzle method was proposed to realize precise and high-throughput rare cell separation. The PIMJ sorter was fabricated by assembling laser-patterned polymer-film layers of different thicknesses. After illustrating the conceptual design and fabrication process, the effects of the cross-sectional dimension, particle size, and operational flow rate on particle focusing were systematically explored under a broad flow rate range. Then, the separation performances of the PIMJ sorter were characterized using the binary particle mixture and the blood samples spiked with four types of tumor cells. The results indicated that the complete separation of the binary particles with a minimum size difference of 2 μm was successfully realized at…
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Fields & Keywords
Physical SciencesEngineeringBiomedical EngineeringMicrofluidic and Bio-sensing TechnologiesMicrofluidic and Capillary Electrophoresis ApplicationsElectrical and Bioimpedance TomographyNanotechnologyChromatographyBiomedical engineeringPedagogyQuantum mechanicsPhysical chemistryOrganic chemistryOceanography