Journal ArticleUnknown
First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist
Authors
Author Affiliations
Lund University, Swedish Armed Forces, Armed Forces Medical College
Published InBrain Research
Year1986
Citations69
Abstract
An antagonist to amino acid evoked excitation, gamma-D-glutamylglycine (gamma-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.
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