Exploring the Protein-Protein Interactions and the Physiological Impact of Cannabinoids through Bioinformatics Analysis

Background: Weed smoking is a vastly unfavorable and perilous practice that can lead to various diseases, but it can also have beneficial effects on the human body. It comprises mainly two bioactive cannabinoids, delta 9-tetrahydrocannabinol and cannabidiol; they have both adverse and beneficial effects on human health. Objective: This study aims to identify the proteins interacting with delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to predict their potential influences on the human body. Materials and Methods: We retrieved 200 proteins from the STITCH and STRING databases to analyze the interaction networks (PCI and PPI). We used OmicsBox to perform functional and pathway analysis of proteins associated with these compounds. Furthermore, the Cytoscape networking tool was utilized to identify crucial proteins and their…