Sajib Chakraborty, Md. Ismail Hosen, Musaddeque Ahmed, Hossain Uddin Shekhar
The acquisition of cancer hallmarks requires molecular alterations at multiple levels including genome, epigenome, transcriptome, proteome, and metabolome. In the past decade, numerous attempts have been made to untangle the molecular mechanisms of carcinogenesis involving single OMICS approaches su...
Sajib Chakraborty, Rajib Chakravorty, Musaddeque Ahmed, Atiqur Rahman et al.
A major problem in designing vaccine for the dengue virus has been the high antigenic variability in the envelope protein of different virus strains. In this study, a computational approach was adopted to identify a multi-epitope vaccine candidate against dengue virus that may be suitable for large ...
Tonmoy Das, Geoffroy Andrieux, Musaddeque Ahmed, Sajib Chakraborty
The manifestations of cancerous phenotypes necessitate alterations at different levels of information-flow from genome to proteome. The molecular alterations at different information processing levels serve as the basis for the cancer phenotype to emerge. To understand the underlying mechanisms that...
Sajib Chakraborty, Ambrosius P. Snijders, Rajib Chakravorty, Musaddeque Ahmed et al.
CRISPRs are a diverse family of DNA repeat sequences that are widely distributed among archaea and bacteria. The CRISPR locus is usually composed of three key elements; direct repeats (DRs), spacer sequences and the cas genes. Although recent studies have suggested that spacers may be of extrachromo...
Sajib Chakraborty, Geoffroy Andrieux, A. M. Mahmudul Hasan, Musaddeque Ahmed et al.
Proteome-centric studies, although have identified numerous lncRNA-encoded polypeptides, lack differential expression analysis of lncRNA-peptidome across primary tissues, cell lines and cancer states. We established a computational-proteogenomic workflow involving re-processing of publicly available...
Shyam Sundar Shaha, Akhi Akter, Ruku Akter, Mehadi Hasan Evan et al.
Background: Weed smoking is a vastly unfavorable and perilous practice that can lead to various diseases, but it can also have beneficial effects on the human body. It comprises mainly two bioactive cannabinoids, delta 9-tetrahydrocannabinol and cannabidiol; they have both adverse and beneficial eff...
Wakil Ahmed, Shah M. Hafizur Rahman, Razib Ahmed, Maftun Ahmed et al.
Background: Tibial plateau fractures are relatively rare fractures and have always been a challenge for orthopedic surgeons. These fractures may result in significant limitations postoperatively if not treated properly. The role of arthroscopic-assisted fixation of tibial plateau fractures has been ...