Calcitonin gene‐related peptide (<scp>CGRP</scp>): A novel target for Alzheimer's disease

Summary Alzheimer's disease ( AD ) is leading cause of death among older characterized by neurofibrillary tangles, oxidative stress, progressive neuronal deficits, and increased levels of amyloid‐ β (A β ) peptides. Cholinergic treatment could be the best suitable physiological therapy for AD . Calcitonin gene‐related peptide ( CGRP ) is a thirty‐seven‐amino acid regulatory neuropeptide resulting from different merging of the CGRP gene, which also includes adrenomedullin, amylin, calcitonin, intermedin, and calcitonin receptor‐stimulating peptide. It is a proof for a CGRP receptor within nucleus accumbens of brain that is different from either the CGRP 1 or CGRP 2 receptor in which it demonstrates similar high‐affinity binding for salmon calcitonin, CGRP , and amylin, a possession which is not shared…