ReviewOpen Access
Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review
Authors
Author Affiliations
International Islamic University Malaysia, Mawlana Bhashani Science and Technology University, INTI International University, Daffodil International University, ...
Published InFrontiers in Pharmacology
Year2022
Citations343
Abstract
Colorectal cancer (CRC) is the second most deadly cancer worldwide. CRC management is challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs and spices used in cooking, practised for generations, have been shown to contain CRC protective effect or even be useful as an anti-CRC adjuvant therapy when used in high doses. Herbs and spices contain many bioactive compounds and possess many beneficial health effects. The chemopreventive properties of these herbs and spices are mainly mediated by the BCL-2, K-ras, and MMP pathways, caspase activation, the extrinsic apoptotic pathway, and the regulation of ER-stress-induced apoptosis. As a safer natural alternative, these herbs and spices could be good candidates for chemopreventive or chemotherapeutic agents for CRC management because…
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