Duncan Q.M. Craig
Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. However, despite the publication of numerous original papers and reviews on the subject, the mechanisms ...
Ryan F. Donnelly, Thakur Raghu Raj Singh, Martin J. Garland, Katarzyna Migalska et al.
Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid upon skin insertion to form continuous, unblockable, hydrogel conduits from attached patch-type drug reservoirs to the dermal microcirculation. ...
Md. Mahbubor Rahman, Md. Badrul Islam, Mohitosh Biswas, Aftab Alam
BACKGROUND: In humans, many diseases are associated with the accumulation of free radicals. Antioxidants can scavenge free radicals and minimize their impact. Therefore, the search for naturally occurring antioxidants of plant origin is imperative. Here, we aimed to investigate the antioxidant and f...
Abdullah Al Shoyaib, Sabrina Rahman Archie, Vardan T. Karamyan
Intraperitoneal (IP) route of drug administration in laboratory animals is a common practice in many in vivo studies of disease models. While this route is an easy to master, quick, suitable for chronic treatments and with low impact of stress on laboratory rodents, there is a common concern that it...
Md. Sanower Hossain, Md. Abdul Kader, Khang Wen Goh, Md. Maidul Islam et al.
Colorectal cancer (CRC) is the second most deadly cancer worldwide. CRC management is challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs and spices used in cooking, practised for generations, have been shown to contain CRC protective effect or even be useful as...
Quangang Zhu, Zhongjian Chen, Pijush Paul, Yi Lü et al.
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeut...
Manoj Kumar, Maharishi Tomar, Ryszard Amarowicz, Vivek Saurabh et al.
(L.) belongs to the Myrtaceae family and it is an important fruit in tropical areas like India, Indonesia, Pakistan, Bangladesh, and South America. The leaves of the guava plant have been studied for their health benefits which are attributed to their plethora of phytochemicals, such as quercetin, a...
Masuhiro Nishimura, Hiroshi YAGUTI, H. Yoshitsugu, Shinsaku Naito et al.
Pairs of forward and reverse primers and TaqMan probes specific to each human cytochrome P450 isoform were prepared. Analysis of the mRNA level of each CYP isoform in total RNA from pooled specimens of various human organs was performed by real-time reverse transcription PCR using an ABI PRISM 7700 ...
Mahmud Tareq Hassan Khan, Arjumand Ather, Kenneth D. Thompson, Roberto Gambari
Herpes simplex viruses (HSV-1 and -2) are important pathogens for humans, especially in the case of highly susceptible adults. Moreover, HSV-2 has been reported to be a high risk factor for HIV infection. Therefore, the discovery of novel anti-HSV drugs deserves great efforts. In this paper, we revi...
Sophia N. Economidou, Cristiane Patricia Pissinato Pere, Andrew Reid, Md Jasim Uddin et al.
3D printed microneedle arrays were fabricated using a biocompatible resin through stereolithography (SLA) for transdermal insulin delivery. Microneedles were built by polymerising consecutive layers of a photopolymeric resin. Thin layers of insulin and sugar alcohol or disaccharide carriers were for...
Rosália Maria Tôrres de Lima, Antonielly Campinho dos Reis, Ag‐Anne Pereira Melo de Menezes, José Victor de Oliveira Santos et al.
Natural dietary agents have attracted considerable attention due to their role in promoting health and reducing the risk of diseases including cancer. Ginger, one of the most ancient known spices, contains bioactive compounds with several health benefits. [6]-Gingerol constitutes the most pharmacolo...
Samina Yesmin, Arkajyoti Paul, Tarannum Naz, A. B. M. Atiqur Rahman et al.
Abstract Background This experiment is conducted to evaluate the anti-inflammatory effect of Piper chaba roots. Methods The in-vitro anti-inflammatory activity of Piper chaba was carried out by human red blood cell (HRBC) membrane stabilization method which includes heat-induced hemolysis and hypo t...
Md Jasim Uddin, Nicolaos Scoutaris, Sophia N. Economidou, Clementine Giraud et al.
In this study, novel 3D printed polymeric microneedle arrays were fabricated for enhanced cisplatin delivery to A-431 epidermoid skin tumours for cancer treatment. The microneedles were built by selectively photopolymerising consecutive layers of a biocompatible photopolymer resin using stereolithog...
Md Selim Reza, Quadir Ma, Syed Shabbir Haider
PURPOSE: The present study was undertaken to investigate the effect of plastic, hydrophilic and hydrophobic types of polymers and their content level on the release profile of drug from matrix systems. As the physico-chemical nature of the active ingredients influence the drug retarding ability of t...
Kumar Bishwajit Sutradhar, Md. Lutful Amin
Abstract Nanotechnology, the science of nano sized particles, has rapidly gained the spotlight in diversified areas including pharmaceutical sector. With the blessings of accurate drug designing and better pharmacological action, it has entered the pharmaceutical arena bringing promising discoveries...