Angiotensin-II, a Potent Peptide, Participates in the Development of Hepatic Dysfunctions

Background: Angiotensin and its precursor’s peptides contribute to multiple biological functions and regulate several important mechanisms like hormone production, fluid balance, growth, and apoptosis throughout the body. The function of Ang-II is generally mediated through AT1R and AT2R which monitor various crucial pathways. Angiotensin receptors are largely expressed in various organs such as kidney, heart, adrenal cortex, smooth muscle, brain, pancreas, endothelial cells as well as liver. Ang-II is now considered responsible for end organ dysfunction particularly mediated through oxidative stress. Keywords: Ang-II, fibrosis, free radicals, inflammation, iron overload, liver diseases.