Silvia de Sanjosé, Wim Quint, Laia Alemany, D.T. Geraets et al.
Background Knowledge about the distribution of human papillomavirus (HPV) genotypes in invasive cervical cancer is crucial to guide the introduction of prophylactic vaccines. We aimed to provide novel and comprehensive data about the worldwide genotype distribution in patients with invasive cervical...
Christina Fitzmaurice, Degu Abate, Naghmeh Abbasi, Hedayat Abbastabar et al.
<h3>Importance</h3> Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the P...
Gary E. Raskob, Nick van Es, Peter Verhamme, Marc Carrier et al.
BACKGROUND: Low-molecular-weight heparin is the standard treatment for cancer-associated venous thromboembolism. The role of treatment with direct oral anticoagulant agents is unclear. METHODS: In this open-label, noninferiority trial, we randomly assigned patients with cancer who had acute symptoma...
James Perry, Normand Laperrière, Christopher J. O’Callaghan, Alba A. Brandes et al.
BACKGROUND: Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to standard radiotherapy (60 Gy over a period of 6 weeks). In elderly patients, more convenient shorter c...
Ophira Ginsburg, Freddie Bray, Michel P. Coleman, Verna Vanderpuye et al.
Each year, more than 2 million women are diagnosed with breast or cervical cancer, yet where a woman lives largely determines whether she will develop one of these cancers, have access to timely and effective diagnostic and treatment services, and ultimately survive. Premature death and disability f...
Md. Sanower Hossain, Hidayah Karuniawati, Ammar Abdulrahman Jairoun, Zannat Urbi et al.
Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the incidence and fatalities related to CRC are growing in developing countries t...
Akram Pourshams, Sadaf G Sepanlou, Kevin S Ikuta, Catherine Bisignano et al.
BACKGROUND: Worldwide, both the incidence and death rates of pancreatic cancer are increasing. Evaluation of pancreatic cancer burden and its global, regional, and national patterns is crucial to policy making and better resource allocation for controlling pancreatic cancer risk factors, developing ...
Md. Lutful Amin
P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents are substrates to it and it impedes the absor...
Justina X. Caushi, Jiajia Zhang, Zhicheng Ji, Ajay Vaghasia et al.
Abstract PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell responses. Single-cell transcriptomics have revealed global T cell dysfunction programs in tumour-infiltrating lym...
Talha Bin Emran, Asif Shahriar, Aar Rafi Mahmud, Tanjilur Rahman et al.
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. ...
Catherine Williamson, Victoria Geenes
In Brief Intrahepatic cholestasis of pregnancy is the most common pregnancy-specific liver disease that typically presents in the third trimester. The clinical features are maternal pruritus in the absence of a rash and deranged liver function tests, including raised serum bile acids. Intrahepatic c...
Eileen E. Parkes, Steven M. Walker, Laura E. Taggart, Nuala McCabe et al.
Background: Previously we identified a DNA damage response-deficient (DDRD) molecular subtype within breast cancer. A 44-gene assay identifying this subtype was validated as predicting benefit from DNA-damaging chemotherapy. This subtype was defined by interferon signaling. In this study, we address...
Neal I. Lindeman, Philip T. Cagle, Mary Beth Beasley, Dhananjay Chitale et al.
OBJECTIVE: To establish evidence-based recommendations for the molecular analysis of lung cancers that are required to guide EGFR- and ALK-directed therapies, addressing which patients and samples should be tested, and when and how testing should be performed. PARTICIPANTS: Three cochairs without co...
Md Shahin Ali, Md Sipon Miah, Jahurul Haque, Mahbubur Rahman et al.
Skin cancer is one of the top three perilous types of cancer caused by damaged DNA that can cause death. This damaged DNA begins cells to grow uncontrollably and nowadays it is getting increased speedily. There exist some researches for the computerized analysis of malignancy in skin lesion images. ...
Debesh Jha, Sharib Ali, Nikhil Kumar Tomar, Håvard D. Johansen et al.
Computer-aided detection, localisation, and segmentation methods can help improve colonoscopy procedures. Even though many methods have been built to tackle automatic detection and segmentation of polyps, benchmarking of state-of-the-art methods still remains an open problem. This is due to the incr...