Effect of Prenatal and Postpartum Vitamin D Supplementation on Circulating Biomarkers of Maternal Bone Metabolism (P24-048-19)

To estimate the dose-dependent effect of prenatal and postpartum vitamin D supplementation on circulating concentrations of biomarkers of maternal bone formation (osteoprotegerin [OPG], osteocalcin [OC], procollagen type 1 amino-terminal propeptide [P1NP], and OPG/RANKL ratio), bone resorption (receptor activator nuclear factor kappa-β ligand [RANKL], and carboxyterminal telopeptide of type 1 collagen [CTX]), and general markers of bone metabolism (fibroblast growth factor 23 [FGF23]), in a pregnancy cohort in Dhaka, Bangladesh. This study is a sub-study of the Maternal Vitamin D for Infant Growth trial, a randomized controlled trial in which women were enrolled at 17–24 weeks gestation and randomized to one of five weekly oral vitamin D3 supplements or placebo regimens during pregnancy and up to 6 months postpartum: group A…