Polymorphism of <i>NAT2, PXR, ABCB1</i> , and <i>GSTT1</i> genes among tuberculosis patients of North Eastern States of India

Abstract Background Anti-tuberculosis drug-induced liver injury (AT-DILI) in tuberculosis (TB) patients has been linked to polymorphisms in genes encoding drug metabolism enzymes and proteins. Objective This study aimed to monitor polymorphisms of NAT2, PXR, ABCB1 , and GSTT1 genes in TB patients from three states (Manipur, Tripura, and Nagaland) in the North Eastern Region of India. Methods Genomic DNA was isolated from the whole blood samples of TB patients (n=219; Manipur:139; Tripura: 60; Nagaland: 20). The TaqMan allelic discrimination assay and statistical tools were used to investigate single nucleotide polymorphisms (SNP) patterns in NAT2, PXR, ABCB1 , and GSTT1 genes. Results In the study population, ten distinct genotypes of the NAT2 gene and single variation in the PXR, ABCB1 ,…