Journal ArticleUnknown
Preliminary data on citrinin kinetics in humans and their use to estimate citrinin exposure based on biomarkers
Author Affiliations
TU Dortmund University, Leibniz Research Centre for Working Environment and Human Factors, Shahjalal University of Science and Technology, Charité - Universitätsmedizin Berlin
Published InToxicology Letters
Year2017
Citations57
Abstract
Citrinin (CIT), a fungal metabolite causing nephrotoxicity, has a tolerable daily intake (TDI) value of 0.2μg/kg bw. Contamination of food with CIT is not sufficiently known to allow dietary exposure assessment. Urinary biomonitoring data are available from cohorts of several countries. However, kinetic information is lacking for CIT, hampering the use of urinary biomonitoring data to estimate the daily intake. We have investigated the kinetics of CIT after oral intake in two human volunteers on two occasions. Urinary excretion showed that ingested CIT undergoes conversion to dihydro-citrinone (DH-CIT) which is then excreted in the urine along with parent compound. The cumulative urinary excretion within 24h was between 32.9% and 70.8% (median 40.2%) of the sum of CIT and DH-CIT ('total…
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