Potential usage of Zerumbone to suppress inflammation: An in silico study

<strong>ABSTRACT</strong> A significant cyclic sesquiterpenoid known as Zerumbone was extracted from <em>Zingiber roseum</em> using the volume liquid chromatographic (VLC) technique. It’s a naturally occurring phytochemical having a variety of physiological properties, including antioxidant, anti-ulcer, and antiproliferative action. This study's major goal was to evaluate Zerumbone's anti-inflammatory effectiveness against the inflammation receptors-Secretory Phospholipase A2 (sPLA2), Cyclooxygenase-2 (COX-2), Tumor Necrosis Factor (TNF-alpha), and Inducible Nitric Oxide Synthase 4 using various in-silico methods. The targeted receptors were obtained from Protein Data Bank, and the ligand was accessed in the Pubchem database. Utilizing the Autodock PyRx platform, which supports Autodock Vina, molecular docking was carried out. Even in the computational prediction, it was revealed that this substance was non-toxic. Receptors exhibiting the highest binding…