Comparative predictive power of serum vs plasma proteomic signatures in feto-maternal medicine

Blood proteins are frequently measured in serum or plasma, as they provide a wealth of information. Differences in the ex-vivo processing of serum and plasma raise concerns that proteomic health and disease signatures derived in serum or plasma differ in content and quality. However, little is known regarding their respective power to predict feto-maternal health outcomes. Predictive power is a sentinel characteristic to determine the clinical utility of biosignatures. To compare the predictive power of serum and plasma proteomic signatures for a physiological pregnancy outcome. Paired serum and plasma samples from 73 women were obtained from biorepositories of a multinational prospective cohort study on pregnancy outcomes. Gestational age at the time of sampling was the predicted outcome, as proteomic signatures…