Christine D. Palmer, Amy Rappaport, Matthew J. Davis, Meghan G. Hart et al.
Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise to exert long-lasting disease control in combination with CPI therapy. Safety, tolerability and recommended phase 2 dose (RP2D) of an individualized, h...
Garry Laverty, Martin McLaughlin, Christopher E. Shaw, Sean P. Gorman et al.
The increasing emergence of multidrug-resistant micro-organisms presents one of the greatest challenges in the clinical management of infectious diseases. Therefore, novel antimicrobial agents are urgently required to address this issue. In this report, we describe the solid phase synthesis, charact...
Fyezah Jehan, Sunil Sazawal, Abdullah H Baqui, Muhammad Imran Nisar et al.
Importance: Worldwide, preterm birth (PTB) is the single largest cause of deaths in the perinatal and neonatal period and is associated with increased morbidity in young children. The cause of PTB is multifactorial, and the development of generalizable biological models may enable early detection an...
Shawn S. Smith, K J Willam, Kurt H. Gerstle, Stein Sture
First Name is required invalid characters Last Name is required invalid characters Email Address is required Invalid Email Address Please select a country... Afghanistan Åland Islands Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua And Barbuda Argentina Armenia Aruba Austra...
Martin W. Bloem, Nasreen Huq, Jonathan Gorstein, Susan Burger et al.
BACKGROUND: Vitamin A deficiency is considered to be an important public health problem in Bangladesh. A universal biannual distribution of high-dose vitamin A capsules has been in place for over the past two decades. This supplementation has been beneficial for preschool children. Bangladesh has be...
Artur Sawicki, Magdalena Żemojtel‐Piotrowska, Julia Maria Balcerowska, Monika J. Sawicka et al.
Coronavirus disease (COVID-19) has been a source of fear around the world. We asked whether the measurement of this fear is trustworthy and comparable across countries. In particular, we explored the measurement invariance and cross-cultural replicability of the widely used Fear of COVID-19 scale (F...
Doris Škorić‐Milosavljević, Rafik Tadros, Fernanda M. Bosada, Federico Tessadori et al.
Rationale: Dextro-transposition of the great arteries (D-TGA) is a severe congenital heart defect which affects approximately 1 in 4,000 live births. While there are several reports of D-TGA patients with rare variants in individual genes, the majority of D-TGA cases remain genetically elusive. Fami...
Felix Achana, Stavros Petrou, Jason Madan, Kamran Khan et al.
BACKGROUND: The 'Prehospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration In Cardiac Arrest' (PARAMEDIC2) trial showed that adrenaline improves overall survival, but not neurological outcomes. We sought to determine the within-trial and lifetime health and...
Julie Bruce, Anower Hossain, Ranjit Lall, Emma Withers et al.
BACKGROUND: Falls and fractures are a major problem. OBJECTIVES: To investigate the clinical effectiveness and cost-effectiveness of alternative falls prevention interventions. DESIGN: Three-arm, pragmatic, cluster randomised controlled trial with parallel economic analysis. The unit of randomisatio...
Camilo Espinosa, Waqasuddin Khan, Rasheda Khanam, Sayan Das et al.
Preterm birth (PTB) is the leading cause of death in children under five, yet comprehensive studies are hindered by its multiple complex etiologies. Epidemiological associations between PTB and maternal characteristics have been previously described. This work used multiomic profiling and multivaria...
Christina Hvilsom, Gernot Segelbacher, Robert Ekblom, Martin C. Fischer et al.
One of the main challenges for conservation today is monitoring and understanding changes in biodiversity. Genetic diversity provides the foundation for biodiversity and is necessary for long-term survival, adaptation, and resilience not only for individuals, but also for populations, species, and e...
João Paulo Silva, Ana Teresa Marques, Joana Bernardino, Tris Allinson et al.
Summary Bustards comprise a highly threatened family of birds and, being relatively fast, heavy fliers with very limited frontal visual fields, are particularly susceptible to mortality at powerlines. These infrastructures can also displace them from immediately adjacent habitat and act as barriers,...
Martin Hilmi, Governance Consultant, G Acheampong, M Esposito et al.
The research was conducted to ascertain, assess and diagnose street food vendors' entrepreneurial marketing characteristics and practices in BOP/subsistence marketplaces and what lessons could be leant that may be of use to improve food marketing in BOP/subsistence marketplaces. The research was con...
on behalf of the Pre-FIT Study Group, Solveig A. Arnadottir, Julie Bruce, Ranjit Lall et al.
BACKGROUND: The aim was to estimate the prevalence of frailty and relative contribution of physical/balance, nutritive, cognitive and sensory frailty to important adverse health states (falls, physical activity levels, outdoor mobility, problems in self-care or usual activities, and lack of energy o...
Camilo Espinosa, Said M. Ali, Waqasuddin Khan, Rasheda Khanam et al.
Blood proteins are frequently measured in serum or plasma, as they provide a wealth of information. Differences in the ex-vivo processing of serum and plasma raise concerns that proteomic health and disease signatures derived in serum or plasma differ in content and quality. However, little is known...