Journal ArticleOpen Access
Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis
Authors
Lei Qiao, Jing Ma, Zihao Zhang, Wenhai Sui, …
Author Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College, Ministry of Education, Jinan Central Hospital, Shandong Provincial Hospital, ...
Published InCirculation Research
Year2021
Citations176
Abstract
Rationale: The NLRP3 (NLR [NOD-like receptor] family, pyrin domain containing 3) inflammasome is an important driver of atherosclerosis. Our previous study shows that chaperone-mediated autophagy (CMA), one of the main lysosomal degradative process, has a regulatory role in lipid metabolism of macrophages. However, whether the NLRP3 inflammasome is regulated by CMA, and the role of CMA in atherosclerosis remains unclear. Objective: To determine the role of CMA in the regulation of NLRP3 inflammasome and atherosclerosis. Methods and Results: The expression of CMA marker, LAMP-2A (lysosome-associated membrane protein type 2A), was first analyzed in ApoE −/− mouse aortas and human coronary atherosclerotic plaques, and a significant downregulation of LAMP-2A in advanced atherosclerosis in both mice and humans was observed. To selectively…
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