Olaf Holz, Rudolf A. Jörres, PETRA TIMM, Marion Mücke et al.
To study whether the individual inflammatory response to ozone was reproducible, dose-dependent, and time-dependent, we performed two exposures to 250 ppb ozone, one to 125 ppb and one to filtered air, each for 3 h of intermittent exercise and separated by at least 1 wk. Twenty-one healthy and 15 as...
Éric Van Ganse, L Kaufman, M.P. Derde, Jean Claude Yernault et al.
A meta-analysis of clinical trials of antihistamines was performed to assess the risk-benefit ratio of this therapeutic class in asthma. Double-blind randomized placebo-controlled trials assessing lung function changes under repeated use of antihistamine in adult asthma were selected, and the qualit...
Jean Bousquet, Erik Melén, Tari Haahtela, Gerard H. Koppelman et al.
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, i...
Amanda M. Burkhardt, Kenneth P. Tai, Juan P. Flores-Guiterrez, Natalia Vilches‐Cisneros et al.
The mucosal immune network is a crucial barrier preventing pathogens from entering the body. The network of immune cells that mediates the defensive mechanisms in the mucosa is likely shaped by chemokines, which attract a wide range of immune cells to specific sites of the body. Chemokines have been...
Eli O. Meltzer, Craig LaForce, Paul H. Ratner, David Price et al.
Many patients with allergic rhinitis (AR) have uncontrolled symptoms despite available treatment options. This study was designed to evaluate the efficacy and safety of MP29-02 (a novel intranasal formulation of fluticasone propionate [FP] and azelastine [AZ] hydrochloride), compared with monotherap...
Nicolas Noulin, Valérie Quesniaux, Silvia Schnyder‐Candrian, Bruno Schnyder et al.
Inhaled endotoxin induces an inflammatory response that contributes to the development and severity of asthma and other forms of airway disease. Here, we show that inhaled endotoxin-induced acute bronchoconstriction, TNF, IL-12p40, and KC production, protein leak, and neutrophil recruitment in the l...
Yang‐Ching Chen, Yu‐Kang Tu, Kuo‐Chin Huang, Pau‐Chung Chen et al.
RATIONALE: Available prospective studies of obesity and asthma have used only body mass index (BMI) as an indicator for adiposity; studies using detailed obesity measures are lacking, and the role of physical fitness level and sedentary time remains unexplored in the link between obesity and asthma....
Melissa J. Whitrow, Seeromanie Harding
RATIONALE: The relative contribution of body proportion and social exposures to ethnic differences in lung function has not previously been reported in the United Kingdom. OBJECTIVES: To examine ethnic differences in lung function in relation to anthropometry and social and psychosocial factors in e...
David Price, Shailen Shah, Sanjay Bhatia, Claus Bachert et al.
BACKGROUND AND OBJECTIVE: MP29-02 (Dymista), a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP), is significantly better than first-line therapy for the treatment of moderate-to-severe seasonal allergic rhinitis (SAR), and is well tolerated following 52 ...
MyLinh Duong, Shofiqul Islam, Sumathy Rangarajan, Koon Teo et al.
Background Despite the rising burden of chronic respiratory diseases, global data for lung function are not available. We investigated global variation in lung function in healthy populations by region to establish whether regional factors contribute to lung function. Methods In an international, co...
A. R. Cameron, C.F. Johnston, C. T. Kirkpatrick, Melanie C. A. Kirkpatrick
The effect of inhibitory nerve stimulation on the mechanical, membrane potential and membrane conductance responses of isolated bovine tracheal smooth muscle has been studied. Membrane responses were measured in a sucrose-gap apparatus. In order to record inhibitory responses, it was necessary to in...
Philip H. Quanjer, Gregg L Ruppel, Arnulf Langhammer, Abhishek Krishna et al.
Background Recommendations on interpreting tests of bronchodilator responsiveness (BDR) are conflicting. We investigated the dependence of BDR criteria on sex, age, height, ethnicity, and severity of respiratory impairment. Methods BDR test data were available from clinical patients in the Netherlan...
Jean Bousquet, Josep M. Antó, Claus Bachert, Tari Haahtela et al.
Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA cha...
S A McKenzie
BACKGROUND AND AIMS: The measurement of airway resistance using the interrupter technique (R(int)) is feasible in preschool children and other subjects unable to undertake spirometry. This makes it potentially useful for the measurement of lung function in these groups. Commercial devices use differ...
Achilleas Floudas, Sean P. Saunders, Tara Moran, Christian Schwartz et al.
Abstract Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide and is associated with dysregulation of the skin barrier. Although type 2 responses are implicated in AD, emerging evidence indicates a potential role for the IL-17A signa...