Sajib Chakraborty, Md. Ismail Hosen, Musaddeque Ahmed, Hossain Uddin Shekhar
The acquisition of cancer hallmarks requires molecular alterations at multiple levels including genome, epigenome, transcriptome, proteome, and metabolome. In the past decade, numerous attempts have been made to untangle the molecular mechanisms of carcinogenesis involving single OMICS approaches su...
Alexandre F. Aissa, Abul Bashar Mir Md. Khademul Islam, Majd Ariss, Cammille C. Go et al.
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, the duration of clinical response is often limited, and patients ultimately develop drug resistance. Here, we u...
P Maxwell, Ryan S. Gallagher, Angela Seaton, Catherine Wilson et al.
Hypoxic cancer cells are resistant to treatment, leading to the selection of cells with a more malignant phenotype. The expression of interleukin-8 (IL-8) plays an important role in the tumorigenesis and metastasis of solid tumors including prostate cancer. Recently, we detected elevated expression ...
Verena Bihrer, Mireen Friedrich‐Rust, Bernd Kronenberger, Nicole Forestier et al.
OBJECTIVES: The liver contains large amounts of microRNA-122 (miR-122), whereas other tissues contain only marginal amounts of this miRNA. MicroRNAs have also been found to circulate in the blood in a cell-free form; their potential as readily accessible disease markers is currently evaluated. Here,...
Shuo Ma, Meiling Zhou, Yanhua Xu, Xinliang Gu et al.
Gastric cancer (GC) is one of the most common tumors worldwide and the leading cause of tumor-related mortality. Endoscopy and serological tumor marker testing are currently the main methods of GC screening, and treatment relies on surgical resection or chemotherapy. However, traditional examination...
Sajib Chakraborty, Taibur Rahman
Cancer is clearly the most deadly disease in the developed world as one in three people develop cancer during their lifetime. The cure for cancer is like the Holy Grail since most of the existing treatments are not effective enough to provide full protection from this disease. In recent years the bu...
Md. Abdullah‐Al‐Kamran Khan, Md. Rabi Us Sany, Md. Shafiqul Islam, Abul Bashar Mir Md. Khademul Islam
Detailed molecular mechanism of SARS-CoV-2 pathogenesis is still elusive to address its deadlier nature and to design effective theraputics. Here, we present our study elucidating the interplay between the SARS-CoV and SARS-CoV-2 viruses’; and host’s miRNAs, an epigenetic regulator, as a mode of pat...
Lorenzo de la Rica, José Urquiza, David Gómez-Cabrero, Abul Bashar Mir Md. Khademul Islam et al.
Autoimmune rheumatic diseases are complex disorders, whose etiopathology is attributed to a crosstalk between genetic predisposition and environmental factors. Both variants of autoimmune susceptibility genes and environment are involved in the generation of aberrant epigenetic profiles in a cell-sp...
Zhengyuan Cheng, Manoj Hang Limbu, Zhi Wang, Jing Liu et al.
Gelatinases are members of the matrix metalloproteinase (MMPs) family; they play an important role in the degradation of the extracellular matrix (ECM). This effect is also crucial in the development and progression of chronic kidney disease (CKD). Its expression, as well as its activity regulation ...
Song-Nian Yin, Richard B. Hayes, Martha S. Linet, Guilan Li et al.
A large cohort study of 74,828 benzene-exposed and 35,805 unexposed workers employed between 1972 and 1987 in 12 cities in China were followed to determine mortality from all causes and the incidence of lymphohematopoietic malignancies and other hematologic disorders. Benzene-exposed study subjects ...
Xiangxiang Liu, Bei Pan, Li Sun, Xiaoxiang Chen et al.
Abstract Background: Colorectal cancer is one of the most common cancers worldwide usually is associated with poor prognosis due to the advanced stage when diagnosed. This study aimed to investigate whether specific circulating exosomal miRNAs could act as biomarkers for early diagnosis of colorecta...
M.M. Hossain, Md Mahmodul Hasan Sohel, K. Schellander, Dawit Tesfaye
Recent progress in high throughput sequencing and bioinformatic analysis and other biochemical methods have fuelled our appreciation for the important role of microRNAs (miRNAs) in disease, fertility and development. These tiny RNAs were found to be potentially involved in various aspects of cellula...
Ralf J.P. van der Valk, Eskil Kreiner‐Møller, Marjolein N. Kooijman, Mònica Guxens et al.
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified...
Irfan A. Asangani, Paul W. Harms, Lois Dodson, Mithil B. Pandhi et al.
// Irfan A. Asangani 1,2,* ,Paul W. Harms 1,2,3,* , Lois Dodson 1 , Mithil Pandhi 1 , Lakshmi P. Kunju 2 , Christopher A. Maher 1,2,4 , Douglas R. Fullen 2,3 , Timothy M. Johnson 3 , Thomas J. Giordano 2 , Nallasivam Palanisamy 1,2,5,8 , Arul M. Chinnaiyan 1,2,5,6,7,8 1 Michigan Center for Translati...
Karishma Sajnani, Farhadul Islam, Robert A. Smith, Vinod Gopalan et al.
Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and energy metabolism. Glycolysis in non-oxygen condition is the main energy production process in cancer rather than mitochondrial respiration as in benign cells. Genetic and epigenetic alterations of Krebs cycle ...