Xiangxiang Liu, Xueni Xu, Bei Pan, Bangshun He et al.
The lack of screening methods with high diagnostic utility leads to colorectal cancer (CRC) patients usually diagnosed in advanced stages which results in high mortality. This study aimed to identify novel circulating miRNAs as biomarkers for the early detection of CRC. Materials and Methods: Total ...
Zineb Hakkou, Alexandre Maciuk, Véronique Leblais, Nour Elhouda Bouanani et al.
Background Inula viscosa L. (Asteraceae) is a medicinal plant widely used as a folk medicine in oriental Morocco, to treat hypertension. The antihypertensive effect of the methanolic extract obtained from I. viscosa leaves was evaluated in hypertensive L-NAME rats. Systolic blood pressure (SBP) was ...
Farhadul Islam, Vinod Gopalan, Jelena Vider, Riajul Wahab et al.
Objectives: The role and underlying mechanism of miR‐186‐5p in colorectal cancer remain unknown. The present study aims to examine the various cellular effects of miR‐186‐5p in the carcinogenesis of colorectal cancer. Also, the interacting targets and association of clinicopathological factors with ...
M.M. Hossain, Dessie Salilew‐Wondim, K. Schellander, Dawit Tesfaye
Advanced genomic analysis has revealed an enormous inventory of non-coding RNAs (ncRNAs), which are functionally important at transcriptional and post-transcriptional level for different cellular processes. Among the ncRNAs, microRNAs (miRNAs) have recently been highlighted extensively for their piv...
Abdus Samad, Farhana Haque, Zulkar Nain, Rahat Alam et al.
≤ 0.05) between the higher MCM2 expression and lower patient survival. Finally, we identified the co-expressed genes with gene ontological features and signaling pathways associated in BC development. We believe that this study will provide a basis for MCM2 to be a significant biomarker for human BC...
Mary Truscott, Abul Bashar Mir Md. Khademul Islam, Maxim V. Frolov
The importance of microRNAs in gene expression and disease is well recognized. However, what is less appreciated is that almost half of miRNA genes are organized in polycistronic clusters and are therefore coexpressed. The mir-11∼998 cluster consists of two miRNAs, miR-11 and miR-998. Here, we descr...
Hong Zhi, Lina Wang, Genshan Ma, Xingzhou Ye et al.
Background MicroRNAs (miRNAs) are small, single-stranded, non-protein-coding RNAs of about 22 nucleotides. miRNA molecules have been identified that plays key roles in a broad range of physiologic and pathologic processes. Polymorphisms in the corresponding sequence space are likely to make a signif...
Abdullah Al Mamun, Hisaki Hayashi, Aya Yamamura, Md Junayed Nayeem et al.
Glucose uptake and adenosine triphosphate (ATP) generation are important for the survival and growth of endothelial cells. An increase of glucose uptake under hypoxia was previously shown to be associated with the increased expression of glucose transporters (GLUTs). However, the regulation of GLUT ...
Huazhang Wu, Ying Hu, Xiufang Liu, Wei Song et al.
Long noncoding RNA (lncRNA) has been implicated in cancer, but little is known about the role of lncRNAs as regulators of tumor metastasis. In the present study, we demonstrate that lncRNA TRERNA1 acts like an enhancer of SNAI1 to promote cell invasion and migration and to contribute to metastasis o...
Wei Song, Chuqian Zheng, Min Liu, Ying Xu et al.
Hepatocellular carcinoma (HCC) is among the most common malignancies and has an unfavorable prognosis. The hepatitis B virus-encoded X (HBx) protein is closely associated with hepatocarcinogenesis. Sorafenib is a unique targeted oral kinase inhibitor for advanced HCC. Long noncoding RNAs (lncRNAs) m...
Xiangrui Qiao, Liang Wang, Mengping Liu, Yuling Tian et al.
Previous studies have shown that miR-210-3p is involved in the development and progression of atherosclerosis, but its specific mechanisms are still unclear. This study aims to reveal the mechanism of miR-210-3p and its target genes in macrophage lipid deposition and inflammatory response, and provi...
Ahsan Ahmad, Hao Lin, Swakkhar Shatabda
Knowledge of the sub-cellular localization of the most diverse class of transcribed RNA, long non-coding RNAs (lncRNAs) will lead us to identify different types of cancers and other diseases as lncRNAs play key role in related cellular functions. In recent days with the exponential growth of known r...
Há Thi Nguyen, Salah Eddine Oussama Kacimi, Truc Ly Nguyen, Kamrul Hassan Suman et al.
MicroRNAs (miRNAs) are small non-coding RNAs. They can regulate the expression of their target genes, and thus, their dysregulation significantly contributes to the development of cancer. Growing evidence suggests that miRNAs could be used as cancer biomarkers. As an oncogenic miRNA, the roles of mi...
Ping Li, Jianjian Peng, Jiangbo Hu, Z. Xu et al.
MicroRNAs (miRNAs) are a kind of endogenous non-coding small RNAs whose specific functions in animals are generally important. Although functions of some miRNAs have been identified, the role of miR-184 remains unknown. Here, we determined the temporal and spatial expression pattern of miR-184 durin...
Atif A Hashmi, Muhammad Muzzammil Edhi, Hanna Naqvi, Naveen Faridi et al.
BACKGROUND: Young age breast cancers are quite prevalent in our setup, a significant number of which exhibit triple negative phenotype. These cancers behave in an aggressive fashion and unresponsive to targeted adjuvant therapy. We aimed to evaluate clinical and histopathologic features of triple ne...