Joshua A Welsh, Deborah C. I. Goberdhan, Lorraine O’Driscoll, Edit I. Buzás et al.
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-ye...
A Hill, Suzanne McFarlane, Karl Mulligan, H. B. Gillespie et al.
Using a validated tetracycline (tet)-regulated MCF7-founder (MCF7F) expression system to modulate expression of CD44 standard form (CD44s), we report the functional importance of CD44s and that of a novel transcriptional target of hyaluronan (HA)/CD44s signaling, EMS1/cortactin, in underpinning brea...
Sean P. Allen, Shabeena Khan, Shui‐Pang Tam, Marlys L. Koschinsky et al.
Lp(a) is a major inherited risk factor for premature atherosclerosis. The mechanism of Lp(a) atherogenicity has not been elucidated, but likely involves both its ability to interfere with plasminogen activation and its atherogenic potential as a lipoprotein particle after receptor-mediated uptake. W...
Daiji Sakata, Hiroyuki Taniguchi, Shingo Yasuda, Aki Adachi-Morishima et al.
Trafficking of immune cells is controlled by directed migration of relevant cells toward chemotactic signals. Actin cytoskeleton undergoes continuous remodeling and serves as machinery for cell migration. The mDia family of formins and the Wiskott-Aldrich syndrome protein (WASP)-Arp2/3 system are tw...
Rupinder Kaur, Varinder Singh, Pratima Kumari, Ravinder J. Singh et al.
Cell adhesion molecules (CAM) including the intracellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) are from the immunoglobulin family which regulates leukocyte adherence to endothelial muscles in acute or chronic inflammatory states [1]. TNF-α, a proinflammatory cy...
Tom Van Agtmael, Matthew A. Bailey, Ursula Schlötzer‐Schrehardt, Eilidh Craigie et al.
Collagen type IV is the major structural component of the basement membrane and COL4A1 mutations cause adult small vessel disease, familial porencephaly and hereditary angiopathy with nephropathy aneurysm and cramps (HANAC) syndrome. Here, we show that animals with a Col4a1 missense mutation (Col4a1...
Katarzyna Wertheim‐Tysarowska, Agnieszka Sobczyńska‐Tomaszewska, Cezary Kowaléwski, Michał Skroński et al.
Dystrophic Epidermolysis Bullosa (DEB) is a genetic disease caused by mutations in the COL7A1 gene that is inherited in the autosomal dominant or recessive mode. We have developed a curated, freely accessible COL7A1 specific database (http://www.col7.info), which contains more than 730 reported and ...
Chenbo Ding, Wendong Tang, Xiaobo Fan, Xiyong Wang et al.
Pseudopodium-enriched atypical kinase 1 (PEAK1), a novel non-receptor tyrosine kinase, has been demonstrated to act as an oncogenic regulator in breast and pancreatic cancers. However, the role of PEAK1 in the progression and metastasis of lung cancer is still unknown. Here, we observed that ectopic...
Shamrat Kumar Paul, Md. Saddam, Khandoker Asiqur Rahaman, Jong‐Gu Choi et al.
identified by its PDB id 1k94_A. Using the SWISS-MODEL server, we used 1k94_A as a template protein to model the mouse GCA protein. Compared to the template structure 1K94, three potential binding sites for calcium-binding have been proposed, ranging from 13 to 20, 80 to 91, and 109 to 120 amino aci...
Benjia Liang, Muhammad Shahbaz, Yang Wang, Huijie Gao et al.
PURPOSE: Adjuvant chemotherapy is one of the significant treatments for colon cancer in clinic. However, it does not achieve the desired therapeutic efficacy, largely due to chemotherapeutic resistance. Integrinβ6 (ITGB6) is expressed in malignant colonic epithelia, but not in normal epithelia, and ...
Helena Aguilar, Ander Urruticoechea, Pasi Halonen, Kazuma Kiyotani et al.
INTRODUCTION: Endocrine therapies targeting cell proliferation and survival mediated by estrogen receptor α (ERα) are among the most effective systemic treatments for ERα-positive breast cancer. However, most tumors initially responsive to these therapies acquire resistance through mechanisms that i...
Justyna Pawłowska, Anna Mikosik, M Soroczynska-Cybula, Agnieszka Jóźwik et al.
Rheumatoid arthritis (RA) and osteoarthritis (OA) are chronic diseases associated with morphological joint changes. Synovial membrane (SM) involvement was established for RA, but the data for OA are limited, because OA is usually regarded as noninflammatory disease. Changes in immune system in RA ar...
Hiroya Kitasaka, Tomoko Kawai, S. A. Masudul Hoque, Takashi Umehara et al.
It has been known that EGF-like factor secreted from LH-stimulated granuloma cells acts on granulosa cells and cumulus cells to induce ovulation process. Granulosa cells are changed the morphology with differentiating cell functions to produce progesterone. Cumulus cells are detached to make a space...
M. De Waele, Wim Renmans, Kristin Jochmans, Rik Schots et al.
The expression of adhesion molecules on CD34+ cells in acute myeloid leukemia (AML) and B-lineage acute lymphoblastic leukemia (B-lineage ALL) was compared with that on the myeloid and B-lymphoid CD34+ cells in normal bone marrow. Bone marrow aspirates of 10 patients with AML, 8 patients with B-line...
M. Z. I. Khan, Mir Rubayet Jahan, Md Nabiul Islam, Ziaul Haque et al.
The distribution and frequency of immunoglobulin (Ig)-containing plasma cells, their variations due to sex, and the mode of secretion of Ig cells into the duct system of the Harderian gland was investigated in broiler and native chickens of both sexes in Bangladesh. The Harderian gland is covered by...